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There has been considerable interest and controversy over the potential clinical role of combination antiretroviral therapy, primarily in the treatment of patients with established HIV infection. In order to model the hematologic toxicity of high-dose combination antiretroviral therapy, the HL60 myeloid leukemia cell line was exposed to zidovudine,(More)
Antimicrobial activity was detected in the 50% ethanolic extract of Ixora coccinea. The effective inhibitory concentration of the extract against both the bacterial test organisms and the fungal test organisms studied was 125 ug mL(-1), beyond which the inhibitory activity declined and the organisms started reviving from the effect of the antimicrobial(More)
Pancreatic malignancies, the fourth leading cause of cancer deaths, have an aggressive behavior with poor prognosis, resulting in a 5-year survival rate of only 4%. It is typically a silent malignancy until patients develop metastatic disease. Targeted radionuclide therapies of cancer such as radiolabeled peptides, which bind to the receptors overexpressed(More)
AZT is widely used in combination with other potentially myelotoxic drugs. Bone marrow suppression may limit the vigor of therapy directed at HIV itself, opportunistic infections, and/or AIDS-associated malignancies. Evidence from an HL60 model suggests that toxicity is of most concern with simultaneous use of multiple agents, and that staggered use of(More)
The efficacy of a drug may be a complex function of the length of drug exposure and the drug concentration. One traditional way to model these variables together has been to look at the area under the curve (AUC) when drug concentration is plotted against time. Experiments in an HL60 leukemia cell model suggest that, for the antineoplastic drug paclitaxel,(More)
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