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Many inflammatory diseases are characterised by persistent and inappropriate neutrophil activation, systemic or localised hypoxia, and bacterial colonisation. Hypoxia represents an important regulator of inflammatory responses because it inhibits neutrophil apoptosis, a process central to the timely resolution of inflammation. Progress in understanding how… (More)
Experimental investigations into the dynamics of cylindrical, laser-driven, high-Mach-number shocks are used to study the thermal cooling instability predicted to occur in astrophysical radiative blast waves. A streaked Schlieren technique measures the full blast-wave trajectory on a single-shot basis, which is key for observing shock velocity oscillations.… (More)
BACKGROUND The neuropsychological consequences of exposure to environmental hypobaric hypoxia (EHH) remain unclear. We thus investigated them in a large group of healthy volunteers who trekked to Mount Everest base camp (5,300 m). METHODS A neuropsychological (NP) test battery assessing memory, language, attention, and executive function was administered… (More)
The user-centred design of an experimental shared-window environment at BNR Europe Limited is discussed. This project is still on-going and we anticipate further valuable results from more experimental iterations with the evolving system this year.
Shocks and blast waves are ubiquitous features readily observed in many astrophysical phenomena (e.g. supernova remnants) and high-energy-density environments. The rapid development of high-power laser systems over the last two decades has made it possible to systematically study such structures on a laboratory scale. Clustered gases are an exceedingly… (More)
Over 40 million people travel to high altitude for both work and pleasure each year, and all of them are at risk of the acute effects of hypoxia. This article reviews the prevention, diagnostic features and treatments of these illnesses.