T. A. Makinson

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Abnormal expression of the nuclear-associated enzyme DNA topoisomerase II (topoisomerase II) has been implicated in the in vitro phenotype of radiation hypersensitive ataxia-telangiectasia (A-T) cells and in modifying sensitivity of eukaryotic cells to topoisomerase II-inhibitor drugs [e.g., the DNA intercalator amsacrine (mAMSA)]. To study such(More)
The antitumour drug camptothecin (CPT) can trap covalently bound topoisomerase I-DNA intermediates as complexes which conceal single-strand scissions. In an attempt to evaluate the cytotoxic potential of these lesions in human cells we have measured: (1) cell cycle delay and cell killing by CPT in primary and transformed fibroblasts, and in lymphoblastoid(More)
The prevalence of primary and secondary enuresis was examined longitudinally in a large sample of New Zealand children at ages 5, 7, and 9 years. While the prevalence of primary enuresis fell over time, secondary enuresis increased in prevalence between 5 and 7 years. There were no sex differences. An examination of some of the developmental and background(More)
Abnormal expression of the nuclear-associated enzyme DNA topoisomerase II (topoisomerase II) has been implicated in the in vitro phenotype of radiation hypersensitive ataxia-telangiectasia (A-T) cells and in modifying sensitivity of eukaryotic cells to topoisomerase IIinhibitor drugs {e.g., the DNA intercalator amsacrine (inAMS \)|. To study such(More)
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