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Antisense oligonucleotide containing an internal, non-nucleotide-based linker promote site-specific cleavage of RNA.
We have designed and synthesized a series of novel antisense methylphosphonate oligonucleotide (MPO) cleaving agents that promote site-specific cleavage on a complementary RNA target. These MPOsExpand
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Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages.
Methylphosphonate (MP) oligodeoxynucleotides (MPOs) are metabolically stable analogs of conventional DNA containing a methyl group in place of one of the non-bonding phosphoryl oxygens. All 16Expand
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Triple-strand-forming methylphosphonate oligodeoxynucleotides targeted to mRNA efficiently block protein synthesis.
Antisense oligonucleotides are ordinarily targeted to mRNA by double-stranded (Watson-Crick) base recognition but are seldom targeted by triple-stranded recognition. We report that certain all-purineExpand
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A non-nucleotide-based linking method for the preparation of psoralen-derivatized methylphosphonate oligonucleotides.
A method is reported for conjugating an analog of 4'-(aminomethyl)-4,5',8- trimethylpsoralen to methylphophonate oligonucleotides. This method enables the psoralen moiety to be coupled to theExpand
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The effect of humidity and temperature on the hardening characteristics of sodium silicate bonded self-setting sand mixes
The hardening characteristics of sodium solicate sands vary considerably and so does the slags, which are by-products of commercial production plants. The effect of variation in temperature andExpand
Effect of additives on hot strength retained strength and breakdown properties of sodium silicate bonded sands
The National Metallurgical Laboratory has developed a self setting agent for use with sodium silicate bonded sand. An attempt has been made to study systematically the effect of some of the commonExpand