Tânia Margarida Lourenço

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OBJECTIVES To assess whether open angle glaucoma (OAG) screening meets the UK National Screening Committee criteria, to compare screening strategies with case finding, to estimate test parameters, to model estimates of cost and cost-effectiveness, and to identify areas for future research. DATA SOURCES Major electronic databases were searched up to(More)
To determine the clinical effectiveness of laparoscopic and laparoscopically assisted surgery in comparison with open surgery for the treatment of colorectal cancer. Open resection is the standard method for surgical removal of primary colorectal tumours. However, there is significant morbidity associated with this procedure. Laparoscopic resection (LR) is(More)
OBJECTIVE To compare the effectiveness and risk profile of newer methods for endoscopic ablation of the prostate against the current standard of transurethral resection. DESIGN Systematic review and meta-analysis. DATA SOURCES Electronic and paper records in subject area up to March 2006. REVIEW METHODS We searched for randomised controlled trials of(More)
OBJECTIVE The aim of this study was to determine the clinical effectiveness and cost-effectiveness of laparoscopic, laparoscopically assisted (hereafter together described as laparoscopic surgery) and hand-assisted laparoscopic surgery (HALS) in comparison with open surgery for the treatment of colorectal cancer. DATA SOURCES Electronic databases were(More)
OBJECTIVE To compare the effectiveness and risk profile of minimally invasive interventions against the current standard of transurethral resection of the prostate. DESIGN Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES Electronic and paper records up to March 2006. REVIEW METHODS We searched for all relevant(More)
OBJECTIVES To determine the clinical effectiveness and cost utility of procedures alternative to TURP (transurethral resection of the prostate) for benign prostatic enlargement (BPE) unresponsive to expectant, non-surgical treatments. DATA SOURCES Electronic searches of 13 databases to identify relevant randomised controlled trials (RCTs). REVIEW(More)
Mesenchymal stem cells (MSCs) are viewed as safe, readily available and promising adult stem cells, which are currently used in several clinical trials. Additionally, their soluble-factor secretion and multi-lineage differentiation capacities place MSCs in the forefront of stem cell types with expected near-future clinical applications. In the present work(More)
Transurethral incision of the prostate gland (TUIP) is perceived as a less morbid surgical alternative to standard transurethral resection of the prostate gland (TURP) for treatment of symptomatic mild to moderate benign prostate enlargement (BPE). We aimed to evaluate comparative clinical effectiveness of the two procedures. Systematic review and(More)
Extracellular matrix (ECM) proteins play a key role during oligodendrogenesis. While fibronectin (FN) is involved in the maintenance and proliferation of oligodendrocyte progenitor cells (OPCs), merosin (MN) promotes differentiation into oligodendrocytes (OLs). Mechanical properties of the ECM also seem to affect OL differentiation, hence this study aimed(More)
OBJECTIVES To identify how decision-makers in the NHS perceive and manage interventional procedures guidance and to determine whether additional information would be useful. METHODS Qualitative study using semi-structured interviews with seven providers, six commissioners and one policy-maker. The framework approach was used to analyse transcribed data,(More)