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- Philip Newsholme, Joaquim Procópio, Manuela Maria Ramos Lima, Tânia Cristina Pithon-Curi, R. A. Curi
- Cell biochemistry and function
- 2003
Glucose is widely accepted as the primary nutrient for maintenance and promotion of cell function. However, we propose that the 5-carbon amino acids, glutamine and glutamate, should be considered to… (More)
- R. A. Curi, Claudia Jacques Lagranha, +5 authors Philip Newsholme
- Journal of cellular physiology
- 2005
Glutamine is the most abundant free amino acid in the body and is known to play a regulatory role in several cell specific processes including metabolism (e.g., oxidative fuel, gluconeogenic… (More)
- Philip Newsholme, Manuela Maria Ramos Lima, +4 authors Rue Curi
- Brazilian journal of medical and biological…
- 2003
Glucose is widely accepted as the primary nutrient for the maintenance and promotion of cell function. This metabolite leads to production of ATP, NADPH and precursors for the synthesis of… (More)
- Tatiana Carolina Alba-Loureiro, Sandro Massao Hirabara, José Roberto Mendonça, Ruy Curi, Tânia Cristina Pithon-Curi
- The Journal of endocrinology
- 2006
Several studies have shown impairment of neutrophil function, a disorder that contributes to the high incidence of infections in diabetes. Since glucose and glutamine play a key role in neutrophil… (More)
- Rue Curi, Philip Newsholme, +4 authors Ana Paula Rodrigues Guimarães
- Brazilian journal of medical and biological…
- 1999
Eric Newsholme's laboratory was the first to show glutamine utilization by lymphocytes and macrophages. Recently, we have found that neutrophils also utilize glutamine. This amino acid has been shown… (More)
- Tânia Cristina Pithon-Curi, Robert Ivan Schumacher, +5 authors R. A. Curi
- American journal of physiology. Cell physiology
- 2003
Nuclear, mitochondrial, and plasma membrane events associated with apoptosis were investigated in rat neutrophils cultivated for 3, 24, and 48 h in the absence or presence of glutamine (0.5, 1.0, and… (More)
- Claudia Jacques Lagranha, Sueli Moreno Senna, +4 authors Tânia Cristina Pithon-Curi
- Medicine and science in sports and exercise
- 2004
INTRODUCTION/PURPOSE
The effect of a single bout of intensive exercise on apoptosis of rat neutrophils and the possible prevention by glutamine administration was examined. The experiments were… (More)
- Philip Newsholme, Fernando Abdulkader, +9 authors Tânia Cristina Pithon-Curi
- Frontiers in bioscience
- 2011
Aberrant alterations in glucose and lipid concentrations and their pathways of metabolism are a hallmark of diabetes. However, much less is known about alterations in concentrations of amino acids… (More)
- Elaine Hatanaka, Adriana Cristina Levada-Pires, Tânia Cristina Pithon-Curi, R. A. Curi
- Free radical biology & medicine
- 2006
The effects of oleic, linoleic, and gamma-linolenic acids on the production of ROS by unstimulated and PMA-stimulated neutrophils were investigated by using five techniques: luminol- and… (More)
- Tânia Cristina Pithon-Curi, Mariza Pires de Melo, R. A. Curi
- Cell biochemistry and function
- 2004
Glucose and glutamine utilization and production of glutamate and lactate were determined for up to 48 h in lymphocytes, monocytes and neutrophils cultured in medium rich in metabolites and vitamins.… (More)