Szilvia Szeghalmy

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BACKGROUND Myelofibrosis (MF) is characterized by accumulation of stromal cells and extracellular matrix. Progression of fibrosis is an important clinical issue and monitoring is required for new therapeutic approaches. Currently, the quantification is based on semiquantitative evaluation of reticulin silver stained slides. We recently reported that(More)
In daily routine the reticulin silver staining is used on bone marrow biopsy samples as a gold standard for the characterization of myelofibrosis, however this method does not provide information about the prefibrotic stage. Recently a specific immunohistochemical method was introduced which may overcome these weaknesses of reticulin staining. Activated(More)
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