Szilard Voros

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Recent developments on the 320 multi-detector CT technologies have made the volumetric acquisition of 4D high resolution cardiac images in a single heart beat possible. In this paper, we present a framework that uses these data to reconstruct the 4D motion of the endocardial surface of the left ventricle (LV) for a full cardiac cycle. This reconstruction(More)
The complex morphological structure of the left ventricular endocardial surface and its relation to the severity of arterial stenosis has not yet been thoroughly investigated due to the limitations of conventional imaging techniques. By exploiting the recent developments in Multirow-Detector Computed Tomography (MDCT) scanner technology, the complex(More)
In this paper, we present a method to simulate and visualize blood flow through the human heart, using the reconstructed 4D motion of the endocardial surface of the left ventricle as boundary conditions. The reconstruction captures the motion of the full 3D surfaces of the complex features, such as the papillary muscles and the ventricular trabeculae. We(More)
BACKGROUND Alterations in gene expression in peripheral blood cells have been shown to be sensitive to the presence and extent of coronary artery disease (CAD). A non-invasive blood test that could reliably assess obstructive CAD likelihood would have diagnostic utility. RESULTS Microarray analysis of RNA samples from a 195 patient Duke CATHGEN registry(More)
Conventional whole-heart CAC quantification has been demonstrated to be insufficient in predicting coronary events, especially in accurately predicting near-term coronary events in high-risk adults. In this paper, we propose a lesion-specific CAC quantification framework to improve CAC's near-term predictive value in intermediate to high-risk populations(More)
BACKGROUND Apoprotein B-containing lipoproteins are atherogenic, but atheroprotective functions of apoprotein A-containing high-density lipoprotein (HDL) particles are poorly understood. The association between lipoproteins and plaque components by coronary computed tomography angiography (CTA) and intravascular ultrasound with radiofrequency backscatter(More)
BACKGROUND The whole-heart coronary artery calcium (CAC) score has poor predictive value for obstructive coronary artery disease (CAD). We hypothesized that vessel- and lesion-specific CAC scores are more accurate. OBJECTIVES To evaluate the usefulness of vessel- and lesion-specific CAC in predicting obstructive CAD and to assess the incremental value(More)
Fig. 1. Velocity field visualization of full heart before systole ABSTRACT Many cardiovascular diseases, such as ischemia and arrhyth-mia, will cause abnormal motion of the myocardium, leading to a change of the blood flow pattern in the heart and an increased risk of the formation of thrombus. In this paper , we propose a new method to use high-resolution(More)
CT-based coronary artery calcium (CAC) scanning has been introduced as a non-invasive, low-radiation imaging technique for the assessment of the overall coronary arterial atherosclerotic burden. A three dimensional CAC volume contains significant clinically relevant information, which is unused by conventional whole-heart CAC quantification methods. In this(More)