Szabolcs Kovács

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In recent years the genetic algorithm (GA) was used successfully to solve many optimization problems. One of the most difficult questions of applying GA to a particular problem is that of coding. In this paper a scheme is derived to optimize one aspect of the coding in an automatic fashion. This is done by using a high cardinality alphabet and optimizing(More)
The introduction of trifluoroalkyl groups into aromatic molecules is an important transformation in the field of organic and medicinal chemistry. However, the direct installation of fluoroalkyl groups onto aromatic molecules still represents a challenging and highly demanding synthetic task. Herein, a simple trifluoroethylation process that relies on the(More)
Approximation of unknown input-output mappings by optimizing approximating functions is important for a number of practical applications. A straightforward method involves dividing the whole input space into small regions and finding the optimal approximating value within each. For such an method to work well the way the input region is divided is very(More)
Efficient copper-catalyzed trifluoromethylation of aromatic iodides was achieved with TMSCF3 in the presence of trimethylborate. The Lewis acid was used to anchor the in situ generated trifluoromethyl anion and suppress its rapid decomposition. Broad applicability of the new trifluoromethylating reaction was demonstrated in the functionalization of(More)
The mechanism of arylation of N-heterocycles with unsymmetric diaryliodonium salts is elucidated. The fast and efficient N-arylation reaction is interpreted in terms of the bifunctionality of the substrate: The consecutive actions of properly oriented Lewis base and Brønsted acid centers in sufficient proximity result in the fast and efficient N-arylation.(More)
Synthesis and utilization of a simple copper on iron catalyst in the coupling of aryl halides with thiols through disulfide intermediate is reported. The iron support of copper catalyst ensures reductive media for the coupling, allows easy removal of the metals by outer magnetic field and enables the recycling of the catalyst.
A flow chemistry-based technique is presented herein for Cu(I)-catalyzed azide–alkyne cycloadditions with a copper on iron bimetallic system as the catalyst and iron powder as a readily available copper-scavenger. The method proved to be rapid and safe as compared with the conventional batch experiment; and by using an in-line copper scavenger, the level of(More)
Several o-(trimethylsilyl)aryl imidazolylsulfonates were synthesized in a simple process and successfully applied in cycloadditions involving benzyne intermediates. The precursor offers an efficient alternative for generating benzynes compared to widely used ortho TMS triflates under similar reaction conditions. With the utilization of this new precursor,(More)
Based on a well-known discrete bifurcation problem (the discretized Euler buckling problem) displaying a highly complex bifurcation diagram, we show how to find fast, global access to the distribution patterns of classical branch-invariants (symmetry groups, nodal properties, stability characteristics), without actually computing the complex diagram. At the(More)
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