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  • Tsutomu Nagata, Toshiharu Yoshino, +10 authors Hideyuki Kanno
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2009 (First Publication: 1 February 2009)
  • In the early 1990's, we reported on the low-molecular selective fXa inhibitor DX-9065a having two amidino groups. However, it had poor oral bioavailability due to its strong basic amidino groups. ToContinue Reading
  • Noriyasu Haginoya, Syozo Kobayashi, +7 authors Takayasu Nagahara
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2004 (First Publication: 1 October 2004)
  • Our exploratory study was based on the concept that a non-amidine factor Xa (fXa) inhibitor is suitable for an orally available anticoagulant. We synthesized and evaluated a series ofContinue Reading
  • Noriyasu Haginoya, Syozo Kobayashi, +4 authors Takayasu Nagahara
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2004 (First Publication: 1 November 2004)
  • Based on the both of results for X-ray studies of tetrahydrothiazolopyridine derivative 1c and FXV673, we synthesized a series of thiazol-5-ylpyridine derivatives containing pyridine N-oxide andContinue Reading