Sylwia Bujkiewicz

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BACKGROUND Etanercept, infliximab and adalimumab are licensed in the UK for the treatment of active and progressive psoriatic arthritis (PsA) in adults who have an inadequate response to standard treatment. OBJECTIVE To determine the clinical effectiveness, safety and cost-effectiveness of these biologic agents in the treatment of active and progressive(More)
OBJECTIVES To compare the use of pair-wise meta-analysis methods to multiple treatment comparison (MTC) methods for evidence-based health-care evaluation to estimate the effectiveness and cost-effectiveness of alternative health-care interventions based on the available evidence. METHODS Pair-wise meta-analysis and more complex evidence syntheses,(More)
Multivariate random effects meta-analysis (MRMA) is an appropriate way for synthesizing data from studies reporting multiple correlated outcomes. In a Bayesian framework, it has great potential for integrating evidence from a variety of sources. In this paper, we propose a Bayesian model for MRMA of mixed outcomes, which extends previously developed(More)
Understanding how complex systems respond to change is of fundamental importance in the natural sciences. There is particular interest in systems whose classical newtonian motion becomes chaotic as an applied perturbation grows. The transition to chaos usually occurs by the gradual destruction of stable orbits in parameter space, in accordance with the(More)
BACKGROUND Decisions about the use of new technologies in health care are often based on complex economic models. Decision makers frequently make informal judgments about evidence, uncertainty, and the assumptions that underpin these models. OBJECTIVES Transparent interactive decision interrogator (TIDI) facilitates more formal critique of decision models(More)
We investigate chaotic electron transport in the lowest miniband of a semiconductor superlattice with a tilted magnetic field. This experimentally accessible non-Kolmogorov-Arnol'd-Moser system involves only stationary electric and magnetic fields, but is dynamically equivalent to a time-dependent kicked harmonic oscillator. The onset of chaos strongly(More)
free survival (PFS) and/or overall survival (OS) as reported outcomes and to create a RCT network accordingly. Fixed and random effects FP models of first/second order were applied on these data and tested for goodness of fit using deviance information criteria. Finally, the best fitting model was used to estimate the hazard function, median PFS, median OS(More)
OBJECTIVES The aim of this study was to examine the use of implicit and explicit Bayesian methods in health technology assessments and to identify whether this has changed over time. METHODS A review of all health technology assessment (HTA) reports of secondary research published by the UK National Institute of Health Research (NIHR) between 1997 and(More)