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Macrophage can adopt several phenotypes, process call polarization, which is crucial for shaping inflammatory responses to injury. It is not known if microglia, a resident brain macrophage population, polarizes in a similar way, and whether specific microglial phenotypes modulate cell death in response to brain injury. In this study, we show that both(More)
BACKGROUND Preterm and term newborns are at high risk of brain damage as well as subsequent cerebral palsy and learning disabilities. Indeed, hypoxia-ischemia (HI), pathogen exposures, and associated intracerebral increase of pro-inflammatory cytokines have all been linked to perinatal brain damage. However, the developmental effects of potential variations(More)
Subarachnoid haemorrhage (SAH) is a major contributor to the burden of stroke on society. Treatment options are limited and animal models of SAH do not always mimic key pathophysiological hallmarks of the disease, thus hindering development of new therapeutics. Inflammation is strongly associated with brain injury after SAH in animals and patients, and(More)
This version is made available in accordance with publisher policies. Please cite only the published version using the reference above. Abstract. Embodied Pedagogical Agents (EPA) are increasingly employed in educational applications, for a variety of users and purposes. However, studies have shown that visual appearance, communicative style, and(More)
Research in affective computing and educational technology has shown the potential of affective interventions to increase student's self-concept and motivation while learning. Our project aims to investigate whether the use of affective interventions in a meta-cognitive tutor can help students achieve deeper modeling of dynamic systems by being persistent(More)
The Affective Meta-Tutoring system is comprised of (1) a tutor that teaches system dynamics modeling, (2) a meta-tutor that teaches good strategies for learning how to model from the tutor, and (3) an affective learning companion that encourages students to use the learning strategy that the meta-tutor teaches. The affective learning companion's messages(More)
PROBLEM Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment. METHOD OF STUDY The inflammatory profile of villous tissue was studied in pregnancies at high-risk of placental dysfunction and compared to uncomplicated pregnancies. The(More)
User modeling in AIED has been extended in the past decades to include affective and motivational aspects of learner's interaction in intelligent tutoring systems. An issue in such systems is researchers' ability to understand and detect students' cognitive and meta-cognitive processes while they learn. In order to study those factors, various detectors(More)