Sylvie Fromont

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The chemotropic guidance cue netrin-1 promotes neurite outgrowth through its receptor Deleted in Colorectal Cancer (DCC) via activation of Rac1. The guanine nucleotide exchange factor (GEF) linking netrin-1/DCC to Rac1 activation has not yet been identified. Here, we show that the RhoGEF Trio mediates Rac1 activation in netrin-1 signaling. We found that(More)
Guanine nucleotide exchange factors (GEFs) activate the Rho GTPases by accelerating their GDP/GTP exchange rate. Some RhoGEFs have been isolated based on their oncogenic potency, and strategies to inhibit their activity are therefore actively being sought. In this study we devise a peptide inhibitor screening strategy to target the GEF activity of Tgat, an(More)
BACKGROUND INFORMATION The large family of GEFs (guanine nucleotide-exchange factors) for Rho GTPases activate the GTPases by accelerating their GDP/GTP exchange. The multidomain protein Trio is the founding member of an intriguing subfamily of Rho-GEFs exhibiting two Rho-GEF and numerous additional domains. The members of the Trio family play an important(More)
Running title: Netrin-1 induces axon outgrowth through the GEF Trio 23 Word count (materials and methods): 1089 24 Word count (introduction, results, discussion): 3787 25 2 Abstract 1 The chemotropic guidance cue netrin-1 promotes neurite outgrowth through its receptor DCC 2 (Deleted in Colorectal Cancer) via activation of Rac1. The guanine nucleotide(More)
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