Sylvie Bonin-Guillaume

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Psychomotor retardation (PMR) is a main symptom of depressive illness. In the elderly, it is associated with the severity of depression and poor prognosis. However, PMR is also commonly associated with normal aging, Therefore, depressive PMR is frequently misinterpreted as the age-related slowing in the elderly, which contributes to poor recognition of(More)
Apathy and depression are the most frequent neuropsychiatric symptoms in Alzheimer's disease (AD). In a cross-sectional observational study of 734 subjects with probable mild AD, we evaluated the prevalence of apathy and depression. After the use of specific diagnostic criteria, we tested the interaction between the two syndromes and their relation with(More)
UNLABELLED BACKGROUND/STUDY CONTEXT: No emotion-induction procedure is clearly recommended to assess the emotional reactivity in the elderly. This study aimed to validate an emotional reactivity procedure in healthy old patients. METHODS Nineteen healthy elders (age range: 66-91 years old) were compared with 19 education- and sex-matched young adults (age(More)
OBJECTIVES Validation in the elderly of the Retardation Rating Scale (RRS), which includes items related to motor and mental retardation but not vegetative items, and may be particularly well-suited for the diagnosis of depression in the elderly. METHODS One hundred and sixty-five geriatric inpatients (105 depressed), aged 65 and over, without dementia,(More)
The aim of this study was to assess the prevalence of long-term antipsychotic (AP) use in community-dwelling patients with dementia considering hospitalization periods as AP exposure or not. A retrospective study was carried out from 2009 to 2012 on a PACA-Alzheimer cohort (which included 31 963 patients in 2009 and 36 442 in 2012 from 5 million(More)
OBJECTIVES To develop a short version of the Retardation Rating Scale (RRS), an observer scale recently validated in geriatric inpatients. METHODS A neuropsychologist used a structured interview to assess 165 geriatric medical inpatients with the observer-rated Hamilton Depression Rating Scale, Montgomery and Asberg Rating Scale and RRS, and completed the(More)
Depression has a high prevalence and a poor outcome in the aged. However, it is often under diagnosed and under treated although treatment with antidepressants at optimal dose and duration can be effective on full remission. Numerous antidepressants are effective but most of them produce side effects. The choice of antidepressants must take into account the(More)
Depressed participants display longer reaction times (RTs) than control participants. The present study was aimed at deciphering which stages of processing are affected by depression in old adults. Sixteen old depressed patients and 16 old healthy volunteers performed a two-choice visual RT task. Signal intensity, stimulus-response mapping and foreperiod(More)
Depression in the elderly is frequent but often unknown (in 30 to 50% of the cases) because of difficulties in detecting or diagnosing it. This is due to the clinical features and prognosis of depression in this kind of population but also to the non-existence of specific diagnostic tests. Most of the authors consider that the most useful diagnostic tests(More)
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