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Several recent studies have provided substantial support for the proposal that a decrease in inhibitory processing may play an important role in cognitive changes occurring in the early stages of Dementia of the Alzheimer Type (DAT). The question addressed by the present study was whether these deficits are the result of the failure of a general inhibitory(More)
OBJECTIVES To examine the association between self assessed driving while sleepy and the risk of serious road traffic accidents (RTAs). DESIGN Prospective cohort study. SETTING France. PARTICIPANTS 13 299 of the 19 894 living members of the GAZEL cohort, workers and recent retirees of a French national utility company followed up since 1989. MAIN(More)
BACKGROUND AND OBJECTIVE To assess the influence of medical conditions on road traffic accidents among a cohort of middle-aged workers and pensioners. STUDY DESIGN AND SETTING A longitudinal study of 13,548 participants from a cohort study of French workers. Follow-up data covered the 1989-2000 period. Adjusted hazards ratios (HR(adj)) for serious(More)
The type A behavior pattern (TABP), characterized by impatience, time urgency, and hostility, was originally developed in relation to coronary heart disease. Since 1986, there has been a debate on whether the TABP is also associated with risky driving behaviors leading to increased risks in road traffic accidents (RTAs). The authors examined prospectively(More)
The objective was to describe at-work and commuting crashes occurring in a cohort of French employees and to investigate occupational risk factors. The subjects were employees of the French national electricity and gas companies, Electricité de France and Gaz de France (EDF-GDF), who volunteered to join a research cohort (the GAZEL cohort which included(More)
BACKGROUND Personal responses to stressful life events are suspected of increasing the risk of serious traffic accidents. METHODS We analyzed data from a French cohort study (the GAZEL cohort), including a retrospective driving behavior questionnaire, from 13,915 participants (10,542 men age 52-62 years and 3373 women age 47-62 years in 2001). Follow-up(More)
OBJECTIVES To test the hypothesis that behavioral predictors of serious road traffic crashes (RTC) are correlated with unfavorable attitudes towards traffic safety. DESIGN Prospective and cross-sectional cohort study. SETTING France PARTICIPANTS 13,447 of the 19,894 living members of the GAZEL cohort, workers and recent retirees of a French national(More)
To investigate the contribution of inhibitory deficits in the deterioration of executive function abilities in Alzheimer's disease (AD), a modified version of the Stroop test was submitted to 44 AD patients and 44 elderly controls. Half of the subjects performed successively the Interference Stroop task, the two control tasks and the Reverse Stroop task,(More)
A growing number of studies report a deterioration of the executive function (EF) in dementia of the Alzheimer type (DAT). To evaluate EFs in DAT, a new version of the Tower of London (TOL) task, originally developed by Shallice (1982), was adapted. The new version of the test was built up in its easiest possible feature in order to be administrable to(More)