Description of the scientific aims We study diseases of the central nervous system at four levels: (a) Elucidation of molecular mechanisms underlying psychiatric disorders (particularly depression and schizophrenia) and Parkinson's disease, (b) develop novel approaches to image depression in vivo (collaboration with Konica Minolta Inc.), (c) develop ex vivo… (More)
Loss of 53BP1 rescues BRCA1 deficiency and is associated with BRCA1-deficient and triple-negative breast cancers (TNBC) and with resistance to genotoxic drugs. The mechanisms responsible for decreased 53BP1 transcript and protein levels in tumors remain unknown. Here, we demonstrate that BRCA1 loss activates cathepsin L (CTSL)-mediated degradation of 53BP1.… (More)
"BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells.