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A role for β2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus.

• Sylvia Lombardo, Julie Catteau, Morgane Besson, Uwe Maskos
• Neurobiology of aging
• 2016

Alzheimer's disease (AD) is characterized by the presence of plaques and tangles. Only certain brain regions are vulnerable to progressive neurodegeneration. It is therefore important to study the… (More)

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

• Wonhee Kim, Liang Ma, +5 authors Giuseppina Tesco
• Molecular Neurodegeneration
• 2018

β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease… (More)

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment.

• Sylvia Lombardo, Uwe Maskos
• Neuropharmacology
• 2015

Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of cholinergic tone,… (More)

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