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- Oliver Gresch, Felix B. Engel, +14 authors K. C. Lun
- Methods
- 2004
The availability of genetically altered cells is an essential prerequisite for many scientific and therapeutic applications including functional genomics, drug development, and gene therapy.… (More)
- Jacqueline K Rose, Karla R. Kaun, Sylvia H. Chen, Catharine H. Rankin
- The Journal of neuroscience : the official…
- 2003
Long-term memory for habituation to tap in Caenorhabditis elegans depends on glr-1, a homolog of mammalian non-NMDA glutamate receptors; mutations in glr-1 blocked long-term memory formation. Green… (More)
- K. Jin, Michelle A LaFevre-Bernt, +7 authors Lisa M. Ellerby
- Proceedings of the National Academy of Sciences…
- 2005
There is no satisfactory treatment for Huntington's disease (HD), a hereditary neurodegenerative disorder that produces chorea, dementia, and death. One potential treatment strategy involves the… (More)
- Adil Khan, Yaoming Wang, +8 authors D. A. Greenberg
- Proceedings of the National Academy of Sciences…
- 2006
Neuroglobin (Ngb), a protein related to myoglobin and hemoglobin but expressed predominantly in the brain, is induced by neuronal hypoxia and cerebral ischemia and protects against hypoxic or… (More)
- Veronica V. Galván, Sylvia H. Chen, +4 authors Dale E. Bredesen
- Journal of neurochemistry
- 2002
The synapse loss and neuronal cell death characteristic of Alzheimer's disease (AD) are believed to result in large part from the neurotoxic effects of beta-amyloid peptide (Abeta), a 40-42 amino… (More)
- Juliette Gafni, Theodora Papanikolaou, +15 authors Lisa M. Ellerby
- The Journal of neuroscience : the official…
- 2012
Huntington's disease (HD) is caused by a mutation in the huntingtin (htt) gene encoding an expansion of glutamine repeats at the N terminus of the Htt protein. Proteolysis of Htt has been identified… (More)
- Jorge M. A. Oliveira, Mika B. Jekabsons, +5 authors David Nicholls
- Journal of neurochemistry
- 2007
Mitochondrial dysfunction is believed to participate in Huntington's disease (HD) pathogenesis. Here we compare the bioenergetic behavior of forebrain mitochondria isolated from different transgenic… (More)
- Jorge M. A. Oliveira, Sylvia H. Chen, +7 authors A Cristina Rego
- The Journal of neuroscience : the official…
- 2006
Evidence suggests that neuronal dysfunction in Huntington's disease (HD) striatum involves deficits in mitochondrial function and in Ca2+ handling. However, the relationship between mitochondria and… (More)
- Alyson L. Peel, Noah Sorscher, Joseph Y. Kim, Veronica V. Galván, Sylvia H. Chen, Dale E. Bredesen
- Neuromolecular medicine
- 2004
The two predominant pathological concomitants of Alzheimer's disease (AD) are senile plaques and neurofibrillary tangles. Although many biochemical studies have addressed the composition and… (More)
Studies in English and Italian have shown that non-fluent Broca’s aphasics find it more difficult to produce verbs than nouns, while some fluent patients (including Wernicke's aphasics and anomics)… (More)