Sylvain Trepout

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— Image denoising is a very important step in Cryo-transmission electron microscopy (cryo-TEM) and energy filtering TEM images, before the three-dimensional reconstruction (tomography reconstruction), because they normally have a problem of high noise level, which causes a loss in the contained information and difficult the process of alignment required for(More)
Image denoising is a very important step in cryo-transmission electron microscopy (cryo-TEM) and the energy filtering TEM images before the 3D tomography reconstruction, as it addresses the problem of high noise in these images, that leads to a loss of the contained information. High noise levels contribute in particular to difficulties in the alignment(More)
Objective The Transition Zone (TZ) is defined as the most proxi-mal region of the cilium overlapping with the most dis-tal region of the basal body. This zone has been shown to play a crucial role in cilia biology since it is considered as the site of sorting of proteins that transit to cilia. Protein complexes housed at this zone are found mutated in(More)
Titanium dioxide (TiO2) anatase nanoparticles (NPs) are metal oxide NPs commercialized for several uses of everyday life. However their toxicity has been poorly investigated. Cellular internalization of NPs has been shown to activate macrophages and neutrophils that contribute to superoxide anion production by the NADPH oxidase complex. Transmission(More)
Accumulating evidence indicates that RNA metabolism components assemble into supramolecular cellular structures to mediate functional compartmentalization within the cytoplasmic membrane of the bacterial cell. This cellular compartmentalization could play important roles in the processes of RNA degradation and maturation. These components include Hfq, the(More)
The 3D reconstruction of the Cryo-Transmission Electron Microscopy (Cryo-TEM) and Energy Filtering TEM images (EFTEM) hampered by the noisy nature of these images, so that their alignment becomes so difficult. This noise refers to the collision between the frozen hydrated biological samples and the electrons beam, where the specimen is exposed to the(More)
In vascular endothelium, adherens junctions between endothelial cells are composed of VE-cadherin (vascular endothelial cadherin), an adhesive receptor that is crucial for the proper assembly of vascular structures and the maintenance of vascular integrity. As a classical cadherin, VE-cadherin links endothelial cells together by homophilic interactions(More)
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