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HIV-1 Nef Downregulates MHC-I by a PACS-1- and PI3K-Regulated ARF6 Endocytic Pathway
The HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the trans-Golgi network (TGN) enables HIV-1 to escape immune surveillance. However, the cellular pathway used by Nef toExpand
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PACS‐2 controls endoplasmic reticulum–mitochondria communication and Bid‐mediated apoptosis
The endoplasmic reticulum (ER) and mitochondria form contacts that support communication between these two organelles, including synthesis and transfer of lipids, and the exchange of calcium, whichExpand
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Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation
The trafficking of ion channels to the plasma membrane is tightly controlled to ensure the proper regulation of intracellular ion homeostasis and signal transduction. Mutations of polycystin‐2, aExpand
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AKAP150, a switch to convert mechano‐, pH‐ and arachidonic acid‐sensitive TREK K+ channels into open leak channels
TREK channels are unique among two‐pore‐domain K+ channels. They are activated by polyunsaturated fatty acids (PUFAs) including arachidonic acid (AA), phospholipids, mechanical stretch andExpand
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TWIK1, a unique background channel with variable ion selectivity
TWIK1 belongs to the family of background K+ channels with two pore domains. In native and transfected cells, TWIK1 is detected mainly in recycling endosomes. In principal cells in the kidney, TWIK1Expand
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Identification of a pH Sensor in the Furin Propeptide That Regulates Enzyme Activation*
The folding and activation of furin occur through two pH- and compartment-specific autoproteolytic steps. In the endoplasmic reticulum (ER), profurin folds under the guidance of its prodomain andExpand
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Potassium Channel Silencing by Constitutive Endocytosis and Intracellular Sequestration*
Tandem of P domains in a weak inwardly rectifying K+ channel 1 (TWIK1) is a K+ channel that produces unusually low levels of current. Replacement of lysine 274 by a glutamic acid (K274E) isExpand
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The Role of Dibasic Residues in Prohormone Sorting to the Regulated Secretory Pathway
The mechanisms by which prohormone precursors are sorted to the regulated secretory pathway in neuroendocrine cells remain poorly understood. Here, we investigated the presence of sorting signal(s)Expand
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The family of K2P channels: salient structural and functional properties
Potassium channels participate in many biological functions, from ion homeostasis to generation and modulation of the electrical membrane potential. They are involved in a large variety of diseases.Expand
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Does Sumoylation Control K2P1/TWIK1 Background K+ Channels?
A novel model for the regulation of cell excitability has recently been proposed. It originates from the observation that the background K(+) channel K2P1 (TWIK1) may be silenced by sumoylation inExpand
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