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Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) induces Ca2+ oscillations and waves in Xenopus laevis oocytes. Microsomes from oocytes exhibit high-affinity binding for Ins(1,4,5)P3, and demonstrate Ins(1,4,5)P3-induced Ca2+ release. The Ins(1,4,5)P3 receptor (InsP3R) was purified from oocyte microsomes as a large tetrameric complex and shown to have a monomer(More)
The receptors for the second messenger inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] form a family of closely related proteins that play an important role in regulating the free intracellular Ca2+ concentration. To test the hypothesis that changing the expression level of Ins(1,4,5)P3 receptors could alter the Ins(1,4,5)P3-mediated Ca2+ signal, we(More)
Although benchmarking has proven to be valuable for large businesses and organizations for quite sometime, up until recently, serious doubts existed as to its usefulness for smaller businesses. In this paper, we present the PDG ® , a benchmarking system meant to evaluate SMEs from an external perspective in order to produce a diagnosis of their performance(More)
The paper describes a system that extracts knowledge from technical English texts. Our basic assumption is that in technical texts syntax is a reliable indication of meaning. Consequently, semantic interpretation of the text starts from surface syntax. The linguistic component of the system uses a broad-coverage, domain-independent parser of English, as(More)
Agent-oriented methodologies and related modeling techniques have become a priority for the development of large scale agent-based systems. Several methodologies have been proposed for the development of multiagent systems (MAS). For the most part, these methodologies remain incomplete: they are either an extension of object-oriented methodo-logies or an(More)
Nosocomial acquisition of microorganisms resistant to multiple antibiotics represents a threat to patient safety. Here we review the mechanisms that have allowed highly resistant strains belonging to the Enterococcus genus to proliferate within our health-care institutions. These mechanisms indicate that decreasing the prevalence of resistant organisms(More)
The free nucleoplasmic Ca2+ concentration ([Ca2+]n) may regulate many nuclear events, such as gene transcription. Since the nucleus may possess the enzymes necessary to generate the second messenger inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), and because the nuclear envelope may enclose an Ins(1,4,5)P3-releasable Ca2+ store, we tested the hypothesis that(More)