Syed S. A. Quadri

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Site-specific homing endonucleases are capable of inducing gene conversion via homologous recombination. Reprogramming their cleavage specificities allows the targeting of specific biological sites for gene correction or conversion. We used computational protein design to alter the cleavage specificity of I-MsoI for three contiguous base pair substitutions,(More)
Information exchange among different architectures has been a massive challenge from the last three decades. Difficulty usually arises when an ideal model that deals with the precise exchange of data among different architectures is needed. Considering the case of military architecture frameworks on a common battle field, exchange of efficient and most(More)
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