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A simple and reproducible avian model of acute hematogenous osteomyelitis is described, and the natural history of the disease has been documented. Infection was induced by intravenous injection of bacteria. Chickens were killed 6, 12, 24, 48, 96, and 192 hours following bacterial inoculation, and the left proximal tibia and distal femur were removed for(More)
A reproducible avian model of acute hematogenous staphylococcal osteomyelitis was used to investigate various aspects of antibiotic therapy using a single antibiotic, cloxacillin. The effects of both delaying antibiotic administration and increasing the frequency of antibiotic administration on the outcome of the disease were evaluated. Following bacterial(More)
Three major vessel types--metaphyseal, epiphyseal and transphyseal vessels--were identified in the region of the growth plate following perfusion of the vasculature of the chicken leg with a solution of Berlin Blue. Following the production of osteomyelitis, obstruction to the blood supply adjacent to the abscess was rapid and was clearly demonstrated due(More)
The acute childhood diseases haematogenous staphylococcal osteomyelitis and septic arthritis were studied concurrently using avian models which closely resemble the human diseases. Ultrastructural studies during the initial stages of bone and joint infection showed that adherence of bacteria to cartilage, bacterial proliferation, cartilage destruction and(More)
A model of acute hematogenous osteomyelitis initiated by injection of Staphylococcus aureus into 29-day-old chickens was used. Transmission electron microscopy showed that the bacteria adhered to exposed cartilage matrix in the metaphyseal region of long bones but not to adjacent vascular linings or to erythrocytes. It is proposed that the combination of(More)
BACKGROUND There are numerous studies about morbidity and mortality, technical complications and in-hospital factors after proximal femoral fracture surgery in the elderly. Although experienced clinicians are often able to make an accurate prediction, little information is available about the factors that allow early determination of whether a patient may(More)
The distal femora and proximal and distal tibiae of 4 weeks old broiler chickens have three main types of blood vessels in the growth plate region-metaphyseal, epiphyseal and transphyseal. The transphyseal vessels extend across the entire thickness of the avian growth plate and provide a means of luminal communication between the metaphysis and epiphysis.
We reviewed the published reports of skeletal cryptococcosis and added three cases to the fifty-six in the literature. Eight of the patients in the reported cases probably did not have primary skeletal cryptococcosis. The potential toxicity of antifungal drugs in current use and the apparent effectiveness of surgical treatment for patients who only have a(More)
A simple and reproducible model of acute haematogenous staphylococcal osteomyelitis is described. Twenty-nine day-old chickens were inoculated intravenously with 10(4)-10(8) viable organisms Staphylococcus aureus per kg body weight and were killed 1-8 days after inoculation. Macroscopic septic foci could be detected within 24 hr of inoculation and were most(More)
Antibiotic therapy and surgical drainage of the bone are the most commonly accepted forms of therapy for acute hematogenous osteomyelitis; the efficacy of these two treatment modalities, however, has not been fully established. Treatment regimens remain empiric and open to much controversy. Many contentious issues concerning the management of this disease(More)