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Piezo1, a mechanically activated ion channel, is required for vascular development in mice
It is demonstrated that Piezo1 is activated by shear stress, the major type of mechanical force experienced by endothelial cells in response to blood flow, which suggests a potential role forPiezo1 in mechanotransduction in adult cardiovascular function and disease. Expand
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
It is demonstrated that LRRC8 proteins together constitute the VRAC pore and that hypotonic stress can activate VRAC through a decrease in cytoplasmic Γ, and that low ionic strength in the absence of an osmotic gradient activates the complexes in bilayers. Expand
Dehydrated Hereditary Stomatocytosislinked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
It is found that all PIEZO1 mutations give rise to mechanically activated currents that inactivate more slowly than wild-type currents, providing insight that helps to explain the increased permeability of cations in RBCs of DHS patients. Expand
Piezo1 ion channel pore properties are dictated by C-terminal region
Important structural motifs of this channel family are described and a glutamate residue within a conserved region adjacent to the last two putative TM domains of the protein is identified that affects unitary conductance and ion selectivity, and modulates pore block. Expand
Structure of the mechanically activated ion channel Piezo1
A high-resolution cryo-electron microscopy structure of the mouse Piezo1 trimer provides a foundation to dissect further how Piezo channels are regulated by mechanical force. Expand
Piezos thrive under pressure: mechanically activated ion channels in health and disease
Cellular mechanotransduction, the process of translating mechanical forces into biological signals, is crucial for a wide range of physiological processes. A role for ion channels in sensingExpand
Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection
A mouse model of hereditary xerocytosis is engineered and it is shown that Plasmodium infection fails to cause experimental cerebral malaria in these mice due to the action of Piezo1 in RBCs and in T cells. Expand
OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels
It is conclusively demonstrated that OSCA1.2, one of the Arabidopsis thaliana O SCA proteins, is an inherently mechanosensitive, pore-forming ion channel. Expand
Correction: Corrigendum: Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
In the first paragraph of the Methods section in this Article, case 8 (K8 in Table 1) was incorrectly referred to as case 4 and the following is the correct sentence: ‘Case 8 (ref. 3) and family 3 were case reports, these patients expressed a moderate form of anaemia and haemolysis without initial evidence of perinatal oedema or pseudohyperkalaemia. Expand
The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice
The results indicate that Piezo2 mediates inflammation- and nerve injury–induced sensitized mechanical pain, and suggest that targeting PIEZO2 might be an effective strategy for treating mechanical allodynia. Expand