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C57BL/6 and DBA/2 were compared in the 5-choice serial reaction time task for differences in performance related to attention and impulsivity. The goal was to examine behavioural processes in mice that may relate to ADHD in humans. Groups of male mice were trained to nose-poke in response to a stimulus light presented randomly in one of five holes; correct(More)
BACKGROUND Nicotine can improve and alcohol can impair attentional performance in rats, but little is known about the effects of mixtures of the two drugs with respect to attention. AIMS The aims were to investigate the effects of alcohol and nicotine alone and when co-administered on performance of a five-choice serial reaction time task, and to examine(More)
Nicotine can improve attentional performance in the rat as assessed by a modified five-choice serial reaction time task (5-CSRTT), but it is not known if the effect is shared with other psychomotor stimulants. This study compared the effects of nicotine, amphetamine, caffeine and methylphenidate on performance in the 5-CSRTT and determined whether(More)
BACKGROUND THE OBJECTIVE OF THIS STUDY WAS TO EVALUATE THOSE FACTORS, BOTH INTRINSIC AND EXTRINSIC TO THE EMERGENCY DEPARTMENT (ED) THAT INFLUENCE TWO SPECIFIC COMPONENTS OF THROUGHPUT: "door-to-doctor" time and dwell time. METHODS We used a prospective observational study design to determine the variables that played a significant role in determining ED(More)
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