Swati Singh

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Schistosomiasis is a common, neglected parasitic disease caused by Schistosoma mansoni. Availability of two specific drug oxamniquine and praziquintel for treatment of the disease is a major concern. Recently NAD+ dependent lysine deacetylases have been identified as new drug targets in pathogens. Sirtuins are NAD+ dependent lysine deacetylases that are(More)
BACKGROUND Hypertensive disorders in pregnancy (HDP) represent a group of conditions associated with high blood pressure during pregnancy. It is an important cause of feto-maternal morbidity and mortality, particularly in developing countries. The aims of the study were to find the prevalence of hypertensive disorders and its associated risk factors among(More)
Withania somnifera (Ashwagandha) is an affluent storehouse of large number of pharmacologically active secondary metabolites known as withanolides. These secondary metabolites are produced by withanolide biosynthetic pathway. Very less information is available on structural and functional aspects of enzymes involved in withanolides biosynthetic pathways of(More)
Job shop scheduling problem is one of the most difficult NP-hard combinatorial optimization problems. Therefore, determining an optimal schedule and controlling and it is considered a difficult task. To achieve high performance in manufacturing firms, a scheduling system should make the right decision at the right time according to system conditions. It is(More)
BACKGROUND Palliative care is the proactive care which seeks to maximize quality of life for people and families facing life-threatening illnesses. OBJECTIVES To ascertain the existing knowledge of palliative care among medical interns and determine the effect of a structured educational intervention on improvement of their knowledge levels. SUBJECTS(More)
Looking to the recent roles of topoisomerases in various types of cancers, in the present paper, a quantitative structure–activity relationship model, based on genetic function approximation (GFA) method, was developed using 41 olivacine derivatives as inhibitors of topoisomerase IIβ (Topo IIβ). The best predictive GFA model explained the biological(More)
In plant sciences, the prodigious significance of micronutrient is unavoidable since plant relies primarily on micronutrient as it has profound influence on array of plant activities. Although micronutrients are abundantly present in the soil but plants usually acquire them in relatively trace amounts; hence, regarded as tracer element. B, Cu, Fe, Mn, Zn(More)
Mitogen-activated protein kinases are serine/threonine-specific protein kinases and they are closely related to cyclin-dependent kinases. They constitute functionally significant family of proteins that is involved in various cellular functions like response to mitogens, osmotic stress, heat shock and proinflammatory cytokines as well as known to play key(More)
In view of recently implicated role of COX-1 in human health and diseases, including cancer, development of safe and selective drugs, as COX-1 inhibitor is desirable. Human COX-1 and COX-2 isozymes have been modeled using in silico tools and relative efficacies of terpenoids as their inhibitors have been investigated by docking. The docking analyses of 10(More)