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The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is a master regulator of metabolism in peripheral tissues, and it has been proposed that PGC-1alpha plays a similar role in the brain. Recent evidence suggests that PGC-1alpha is concentrated in GABAergic interneurons, so we investigated whether(More)
It has been established that regulation of chromatin structure through post-translational modification of histone proteins, primarily histone H3 phosphorylation and acetylation, is an important early step in the induction of synaptic plasticity and formation of long-term memory. In this study, we investigated the contribution of another histone(More)
Recent advances in chromatin biology have identified a role for epigenetic mechanisms in the regulation of neuronal gene expression changes, a necessary process for proper synaptic plasticity and memory formation. Experimental evidence for dynamic chromatin remodeling influencing gene transcription in postmitotic neurons grew from initial reports describing(More)
Recent research on conversational agents emphasises the need to build affective conversational systems with social intelligence. Politeness is an integral part of socially appropriate and affective conversational behaviour, e.g. consider the difference in the pragmatic effect of realizing the same communicative goal with either " Get me a glass of water(More)
Controlled, transient cytokine production by monocytes depends heavily upon rapid mRNA degradation, conferred by 3' untranslated region-localized AU-rich elements (AREs) that associate with RNA-binding proteins. The ARE-binding protein AUF1 forms a complex with cap-dependent translation initiation factors and heat shock proteins to attract the mRNA(More)
Adenomatoid odontogenic tumor (AOT) is a rare tumor of epithelial origin comprising 3% of all the odontogenic tumors. It is a benign, painless, noninvasive, and slow-growing lesion, with a relative frequency of 2.2-13% and often misdiagnosed as an odontogenic cyst on clinical examination. AOT affects young individuals with a female predominance, occurs(More)
Politeness is an integral part of human language variation, e.g. consider the difference in the pragmatic effect of realizing the same communicative goal with either " Get me a glass of water mate! " or " I wonder if I could possibly have some water please? " This paper presents POLLy (Politeness for Language Learning), a system which combines a natural(More)
Humans do not learn new tasks in isolation: for instance speech recognition interacts with speaker recognition. Multitask Learning (MTL) attempts to take advantage of these interactions by adding additional, related tasks to the main task. In this work, we present applications of MTL to Automatic Speech Recognition in noise, incorporating speech enhancement(More)