Swarna Kanchan

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Cyanobacteria are known to endure various stress conditions due to the inbuilt potential for oxidative stress alleviation owing to the presence of an array of antioxidants. The present study shows that Antarctic cyanobacterium Nostoc commune possesses two antioxidative enzymes viz., superoxide dismutase (SOD) and catalase that jointly cope with(More)
DNA repair refers to a collection of processes by which a cell identifies and corrects damage to DNA molecules that encodes its genome. In this study, we examined evolution of O6-Methylguanine DNA alkyltransferase (MGMT), Xeroderma pigmentosum group D (XPD) protein, G/T mismatch-specific DNA glycosylases, MutS DNA repair proteins of Escherichia coli,(More)
The group of antigen 85 proteins of Mycobacterium tuberculosis is responsible for converting trehalose monomycolate to trehalose dimycolate, which contributes to cell wall stability. Here, we have used a serial enrichment approach to identify new potential inhibitors by searching the libraries of compounds using both 2D atom pair descriptors and binary(More)
Point mutations in the dhfr and dhps genes of Plasmodium falciparum are associated with pyrimethamine and sulfadoxine resistance respectively. In this study we have analyzed these genes from Bikaner (situated in North-West region of India), where both uncomplicated and severe manifestations of P. falciparum malaria are seen. A majority of isolates showed(More)
The present study focus on the lipid lowering potential of aqueous ethanolic extract of Eugenia caryophyllus in high fat diet induced hyperlipidemia. Hyperlipidemia was induced in rats by oral administration of high fat diet for six weeks. The extract was thereafter administered at two different doses of 200mg/kg and 400mg/kg body weight for next six weeks(More)
DNA repair refers to a collection of processes by which a cell identifies and corrects damage to genomic DNA molecules. DNA repair processes significantly overcome DNA damage and restore the normal nucleotide sequence and DNA structure. This study focuses on the evolution of the endonuclease III gene/protein family, which plays a key role in the base(More)
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