Swapna Menon

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BACKGROUND Vascular elasticity is crucial for maintaining hemodynamics. Molecular mechanisms involved in human elastogenesis are incompletely understood. We describe a syndrome of lethal arteriopathy associated with a novel, identical mutation in the fibulin 4 gene (FBLN4) in a unique cohort of infants from South India. METHODS Clinical characteristics,(More)
The construction and application of biological network models is an approach that offers a holistic way to understand biological processes involved in disease. Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disease of the airways for which therapeutic options currently are limited after diagnosis, even in its earliest stage. COPD(More)
Understanding differences in gene expression that increase risk for pulmonary arterial hypertension (PAH) is essential to understanding the molecular basis for disease. Previous studies on patient samples were limited by end-stage disease effects or by use of nonadherent cells, which are not ideal to model vascular cells in vivo. These studies addressed the(More)
The majority of pulmonary arterial hypertension (PAH) is not associated with BMPR2 mutation, and major risk factors for idiopathic PAH are not known. The objective of this study was to identify a gene expression signature for IPAH. To accomplish this, we used Affymetrix arrays to probe expression levels in 86 patient samples, including 22 healthy controls,(More)
Biological network models offer a framework for understanding disease by describing the relationships between the mechanisms involved in the regulation of biological processes. Crowdsourcing can efficiently gather feedback from a wide audience with varying expertise. In the Network Verification Challenge, scientists verified and enhanced a set of 46(More)
Genesis of myofibroblasts is obligatory for the development of pathology in many adult lung diseases. Adult lung tissue contains a population of perivascular ABCG2(pos) mesenchymal stem cells (MSC) that are precursors of myofibroblasts and distinct from NG2 pericytes. We hypothesized that these MSC participate in deleterious remodeling associated with(More)
Rapid access to lung-derived cells from stable subjects is a major challenge in the pulmonary hypertension field, given the relative contraindication of lung biopsy. In these studies, we sought to demonstrate the importance of evaluating a cell type that actively participates in disease processes, as well as the potential to translate these findings to(More)
Pulmonary vascular disease is characterized by remodeling and loss of microvessels and is typically attributed to pathological responses in vascular endothelium or abnormal smooth muscle cell phenotypes. We have challenged this understanding by defining an adult pulmonary mesenchymal progenitor cell (MPC) that regulates both microvascular function and(More)
Shennea Marriott, Rubin S. Baskir, Christa Gaskill, Swapna Menon, Erica J. Carrier, Janice Williams, Megha Talati, Karen Helm, Catherine E. Alford, Jonathan A. Kropski, James Loyd, Lisa Wheeler, Joyce Johnson, Eric Austin, Eva Nozik-Grayck, Barbara Meyrick, James D. West, Dwight J. Klemm, and Susan M. Majka Department of Medicine, Division of Allergy,(More)
James D. West, Eric D. Austin, Christa Gaskill, Shennea Marriott, Rubin Baskir, Ganna Bilousova, Jyh-Chang Jean, Anna R. Hemnes, Swapna Menon, Nathaniel C. Bloodworth, Joshua P. Fessel, Johnathan A. Kropski, David Irwin, Lorraine B. Ware, Lisa Wheeler, Charles C. Hong, Barbara Meyrick, James E. Loyd, Aaron B. Bowman, Kevin C. Ess, Dwight J. Klemm, Pampee P.(More)
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