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We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction proteins homologous to invertebrate innexins, which constitute a new family of mammalian proteins called pannexins. Phylogenetic analysis revealed that pannexins are highly conserved in worms, mollusks, insects and mammals, pointing to their important function. Both innexins and(More)
In the present study, we describe the human and mouse RFP2 gene structure, multiple RFP2 mRNA isoforms in the two species that have different 5' UTRs and a human-specific antisense transcript RFP2OS. Since the human RFP2 5' UTR is not conserved in mouse, these findings might indicate a different regulation of RFP2 in the two species. The predicted human and(More)
BACKGROUND It has been recently reported that major pathogens Staphylococcus aureus and Pseudomonas aeruginosa accelerate a normal process of cell surface syndecan-1 (Synd1) ectodomain shedding as a mechanism of host damage due to the production of shedding-inducing virulence factors. We tested if acceleration of Synd1 shedding takes place in vitro upon(More)
Ethanol (1--5 g/kg, per os) dose-response curve for locomotion in male mice of 4 strains (SHR, BALB/c, C3HA and C57BL/6) is characterized by a gradual rise up to the top (at 3 g/kg for all strains except C3HA, in which it was attained at 5 g/kg) and by subsequent decline. The dose-response curve for rearings gradually and gently slopes down to zero. The(More)
Ethanol increased the exploratory locomotion of BALB/c mice over a wide dose range (1.15--3.1 g/kg orally), whereas only a 2.31 g/kg dose of ethanol increased the locomotion of C57BL/6 mice. After 1.15 g/kg of ethanol the blood concentrations in BALB/c and C57BL/6 mice were 65 +/- 11 and 68 +/- 13 mg %, respectively, and after 2.3 g/kg--the corresponding(More)
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