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Tumor necrosis factor-alpha/interleukin-10 balance in normal and cystic fibrosis children.
BACKGROUND: The balance between tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) is important for immune homeostasis maintenance. Exuberant production of TNF-alpha contributes toExpand
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Anti-inflammatory and immunomodulating effects of clarithromycin in patients with cystic fibrosis lung disease.
BACKGROUND AND AIM: Macrolide antibiotics are widely used in the treatment of suppurative lung diseases including cystic fibrosis (CF), the most common inherited fatal disease in the CaucasianExpand
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Stimulatory effect of fragments from transcribed region of ribosomal repeat on human peripheral blood lymphocytes
Fragments from the transcribed region of the ribosomal repeat include considerable amounts of unmethylated CpG DNA motifs. These motifs activate immune cells via the interaction with Toll receptors.Expand
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Inflammatory markers in cystic fibrosis patients with lung Pseudomonas aeruginosa infection.
Chronic endobronchial inflammation and bacterial infection are the main causes of morbidity and mortality in cystic fibrosis (CF), an autosomal recessive genetic disorder associated with improperExpand
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Improvement of nutrient absorption may enhance systemic oxidative stress in cystic fibrosis patients.
BACKGROUND: The life expectancy of patients with cystic fibrosis (CF) is largely dependent on the pulmonary disease severity and progress. Malnutrition may be an important complicating factor inExpand
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Effect of semisynthetic analog of α1-acid glycoprotein on immunomodulatory and antiinflammatory activity of natural glycoproteinglycoprotein on immunomodulatory and antiinflammatory activity of
Pseudo-α1-acid glycoprotein with carbohydrate chain ratio typical of native form was synthesized by a previously developed original technique of quantitative transfer of α1-acid glycoproteinExpand
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Immunomodulating effects of tofizopam (Grandaxin) and diazepam in vitro.
Benzodiazepines (BDZs) are known to act not only in the central nervous system, but on peripheral cells and tissues binding to the peripheral-type benzodiazepine receptors. In the present study, theExpand
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[CpG-DNA inhibits cell reactions accompanied with the development of the adaptive response in human lymphocytes after low-dose X-ray exposure].
The lymphocytes of peripheral blood of healthy donors were influenced by X-ray radiation (10 cGy) or a fragments of the transcribed region of rDNA (TRrDNA) transmitted to the incubation medium ofExpand
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[Stress signaling between human lymphocytes after induction of bystander effect by exposure to ionizing radiation in adaptive doses].
We previously reported that the consequence of human lymphocytes irradiation by the adaptive doses (X-rays, 10 cGy) was a transposition of the homologous chromosome loci in the cell nucleus (FISHExpand
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Effect of semisynthetic analog of alpha(1)-acid glycoprotein on immunomodulatory and antiinflammatory activity of natural glycoprotein.
Pseudo-alpha(1)-acid glycoprotein with carbohydrate chain ratio typical of native form was synthesized by a previously developed original technique of quantitative transfer of alpha(1)-acidExpand
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