Svetlana Lebedeva

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This paper describes the Sixth Data Release of the Sloan Digital Sky Survey. With this data release, the imaging of the Northern Galactic Cap is now complete. The survey contains images and parameters of roughly 287 million objects over 9583 deg 2 , including scans over a large range of Galactic latitudes and longitudes. The survey also includes 1.27(More)
The SkyServer is an Internet portal to the Sloan Digital Sky Survey Catalog Archive Server. From 2001 to 2006, there were a million visitors in 3 million sessions generating 170 million Web hits, 16 million ad-hoc SQL queries, and 65 million page views. The site currently averages 35 thousand visitors and 400 thousand sessions per month. The Web and SQL(More)
microRNAs (miRNAs) are small noncoding RNAs that mediate post-transcriptional gene regulation and have emerged as essential regulators of many developmental events. The transcriptional network during early embryogenesis of the purple sea urchin, Strongylocentrotus purpuratus, is well described and can serve as an excellent model to test functional(More)
OBJECT To study the combined potential of wild-type p53 gene transfer and administration of cisplatin for the treatment of glioblastoma multiforme, the authors used the 9L rat glioblastoma cell line, which expresses a mutant p53. METHODS Stable expression of wild-type p53 in 9L cells was achieved by transfection of the cells with a wild-type(More)
The RNA-binding protein FUS is implicated in transcription, alternative splicing of neuronal genes and DNA repair. Mutations in FUS have been linked to human neurodegenerative diseases such as ALS (amyotrophic lateral sclerosis). We genetically disrupted fus in zebrafish (Danio rerio) using the CRISPR-Cas9 system. The fus knockout animals are fertile and(More)
Spatial memory was studied in 2-month-old offspring of rats subjected to different types of experimental preeclampsia (replacement of drinking water with 1.8% NaCl from day 1 to 21 of gestation or intraperitoneal administration of non-selective NO-synthase inhibitor L-NAME to pregnant rats in a daily dose of 25 mg/kg for 7 days on gestation days 14-20).(More)
We studied chronic toxicity of a few release-active preparations: Dietressa (release-active preparation of affinity-purified antibodies to type 1 cannabinoid receptor), Divasa (releaseactive preparation containing a combination of affinity-purified antibodies to brain-specific S-100 protein and endothelial NO-synthase), Cardostin (release-active preparation(More)
BACKGROUND Our aim was to investigate the effect of derivatives of GABA and glutamate on the postnatal development of the offspring of rats with experimental preeclampsia. METHODS The experiments were performed on 35 albino female rats aged 5-7 months, weighing 220-240 g, and their offspring in the amount of 284 individuals. Experimental preeclampsia was(More)
We studied the efficiency of Dietressa on body weight reduction in C57Bl/6 male mice feeding standard high-fat ration (24%). After 5-month daily intragastric administration of Dietressa, body weight gain was the lowest in comparison with other groups and did not differ from that in mice receiving the reference substance sibutramine for 5 months. In contrast(More)
Traditionally, collection of information from synaptic inputs distributed on dendrites and transmission of this information to the soma of the neuron were believed to be the only functions of these neuron compartments. In recent years, such a viewpoint was revised to a considerable extent due to novel results demonstrating that the dendrites can realize the(More)