Svenja Dorothea Steinbrink

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Leukotrienes constitute a group of bioactive lipids generated by the 5-lipoxygenase (5-LO) pathway. An increasing body of evidence supports an acute role for 5-LO products already during the earliest stages of pancreatic, prostate, and colorectal carcinogenesis. Several pieces of experimental data form the basis for this hypothesis and suggest a correlation(More)
In the recent years the prevalent paradigm in drug discovery of " one drug – one target – one disease " , following the assumption that highly selective ligands would avoid unwandted side effects caused by binding to sec-onday non-theratpeutic targets, got reconsidered. The results of post-genomic and network biology showed that proteins rarely act in(More)
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