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  • Jürgen Günther Okun, Friederike Hoerster, +7 authors Stefan Kölker
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2002 (First Publication: 26 April 2002)
  • Methylmalonic acidurias are biochemically characterized by an accumulation of methylmalonate (MMA) and alternative metabolites. There is growing evidence for basal ganglia degeneration in theseExpand
  • Sven Wolfgang Sauer, Jürgen Günther Okun, +10 authors Stefan Kölker
  • Biology, Medicine
  • Journal of neurochemistry
  • 2006 (First Publication: 1 May 2006)
  • Glutaric acid (GA) and 3-hydroxyglutaric acids (3-OH-GA) are key metabolites in glutaryl co-enzyme A dehydrogenase (GCDH) deficiency and are both considered to be potential neurotoxins. As cerebralExpand
  • Marcin M. Kamiński, Sven Wolfgang Sauer, +4 authors Karsten Gülow
  • Biology, Medicine
  • The Journal of Immunology
  • 2010 (First Publication: 1 May 2010)
  • This article shows that T cell activation-induced expression of the cytokines IL-2 and -4 is determined by an oxidative signal originating from mitochondrial respiratory complex I. We also reportExpand
  • Julia Strathmann, Karin Klimo, Sven Wolfgang Sauer, Jürgen Günther Okun, Jochen H. M. Prehn, Clarissa Gerhäuser
  • Chemistry, Medicine
  • FASEB journal : official publication of the…
  • 2010 (First Publication: 1 August 2010)
  • Oxidative stress and increased release of reactive oxygen species (ROS) are associated with apoptosis induction. Here we report ROS-mediated induction of apoptosis by xanthohumol (XN) from hops. XNExpand
  • Stefan Kölker, Marina A Schwab, +7 authors Jürgen Günther Okun
  • Chemistry, Medicine
  • Journal of Biological Chemistry
  • 2003 (First Publication: 28 November 2003)
  • Methylmalonic acidurias are biochemically characterized by an accumulation of methylmalonic acid and alternative metabolites. An impairment of energy metabolism plays a key role in theExpand
  • Marcin M. Kamiński, Daniel Roeth, Sabine Sass, Sven Wolfgang Sauer, Peter H. Krammer, Karsten Gülow
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2012 (First Publication: 1 May 2012)
  • Mitochondrial reactive oxygen species (ROS) are indispensible for T cell activation-induced expression of interleukin 2 (IL-2) and CD95 ligand (CD95L, FasL/Apo-1L) genes, and in turn, forExpand