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BACKGROUND The pathology associated to cholesteatoma is predominantly a consequence of osteoclast-mediated bone resorption within the middle ear. To assess its pathogenesis a murine model for dermal-implant induced osteolysis was evaluated for the expression of osteoclast stimulating and differentiating factors. METHODS Mouse calvaria were analysed for(More)
INTRODUCTION Chondrosarcomas belong to the most common malignomas of the skeletal system. The vast majority is located at the epiphysis of the long bones or in the pelvis. Less than 10% of chondrosarcomas are located in the head and neck area, most common in the bony viscerocranium and the larynx. Five histological variants can be differentiated:(More)
In this paper we summarise the lessons learnt from our EU research project TIMBUS that deals with digital preservation. Digital preservation aims at ensuring continued access to digital information over time or technology changes and as such affects and utilises software design, development and maintenance (cf. [1]). There are numerous technical challenges(More)
BACKGROUND Malignomas of the nasal cavity and the paranasal sinuses count for less than 3 % of the ENT-malignancies. PATIENTS AND METHODS This retrospective chart review reports about 46 patients that were first diagnosed and treated with a nasal cavity or paranasal sinus malignancy between 1998 and 2002 in the ENT department of the Ruhr-Universität(More)
Digital preservation ensures continued access to digital information over time (e.g., 5, 15, 25 or 50 years). The long-term planning horizon of preserving relevant parts of a business processes raises a number of new research challenges for software design, development and maintenance (cf. [1]). In this paper we describe the challenges caused by the(More)
Sensorineural hearing impairment is caused by pathologies within the cochlear portion of the inner ear or the central auditory pathway. Within the last decade, tremendous progress has been made in inner ear biology, thus greatly increasing our understanding of congenital and acquired inner ear pathologies. Moreover, the discovery of hair cell regeneration(More)
BACKGROUND Muramidase and lactoferrin are important components of the antimicrobial defense system. Muramidase has the ability of opsonization and immunopotentiation and therefore a close relation to the lymphatic tissue. Till now there are only immunohistochemical and microbiological studies on the presence of muramidase and lactoferrin in adenoid and(More)
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