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VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice.

• Sven Enterlein, Kelly Lyn Warfield, +7 authors Elke Mühlberger
• Antimicrobial agents and chemotherapy
• 2006

Phosphorodiamidate morpholino oligomers (PMO) are a class of uncharged single-stranded DNA analogs modified such that each subunit includes a phosphorodiamidate linkage and morpholine ring. PMO… (More)

Antiviral activity of a small-molecule inhibitor of filovirus infection.

• Travis Warren, Kelly Lyn Warfield, +8 authors Sina Bavari
• Antimicrobial agents and chemotherapy
• 2010

There exists an urgent need to develop licensed drugs and vaccines for the treatment or prevention of filovirus infections. FGI-103 is a low-molecular-weight compound that was discovered through an… (More)

The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals.

• Martina Trunschke, Dominik Conrad, Sven Enterlein, Judith Olejnik, Kristina Brauburger, Elke Mühlberger
• Virology
• 2013

The Ebola virus (EBOV) RNA-dependent RNA polymerase (RdRp) complex consists of the catalytic subunit of the polymerase, L, and its cofactor VP35. Using immunofluorescence analysis and… (More)

Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae

• Jens H Kuhn, Yīmíng Bào, +34 authors Stuart T Nichol
• Archives of Virology
• 2012

The task of international expert groups is to recommend the classification and naming of viruses. The International Committee on Taxonomy of Viruses Filoviridae Study Group and other experts have… (More)

Rescue of recombinant Marburg virus from cDNA is dependent on nucleocapsid protein VP30.

• Sven Enterlein, Viktor V Volchkov, +4 authors Elke Mühlberger
• Journal of virology
• 2006

Here we report recovery of infectious Marburg virus (MARV) from a full-length cDNA clone. Compared to the wild-type virus, recombinant MARV showed no difference in terms of morphology of virus… (More)

Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen.

• Kevin B. Spurgers, Tim Alefantis, +9 authors Sina Bavari
• Molecular & cellular proteomics : MCP
• 2010

An assessment of the total protein composition of filovirus (ebolavirus and marburgvirus) virions is currently lacking. In this study, liquid chromatography-linked tandem mass spectrometry of… (More)

Development of a broad-spectrum antiviral with activity against Ebola virus.

• M Javad Aman, Michael S. Kinch, +10 authors Sina Bavari
• Antiviral research
• 2009

We report herein the identification of a small molecule therapeutic, FGI-106, which displays potent and broad-spectrum inhibition of lethal viral hemorrhagic fevers pathogens, including Ebola, Rift… (More)

Establishment and characterization of plasmid-driven minigenome rescue systems for Nipah virus: RNA polymerase I- and T7-catalyzed generation of functional paramyxoviral RNA.

• Alexander N. Freiberg, Lhia Krista Dolores, Sven Enterlein, Ramon Flick
• Virology
• 2008

In this study we report the development and optimization of two minigenome rescue systems for Nipah virus, a member of the Paramyxoviridae family. One is mediated by the T7 RNA polymerase supplied… (More)

Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae

• Jens H Kuhn, Yīmíng Bào, +47 authors Stuart T Nichol
• Archives of Virology
• 2012

The International Committee on Taxonomy of Viruses (ICTV) organizes the classification of viruses into taxa, but is not responsible for the nomenclature for taxa members. International experts… (More)

A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire.

• Yannik Boehmann, Sven Enterlein, Anke Randolf, Elke Mühlberger
• Virology
• 2005

The only known filovirus, which presumably is not pathogenic for humans, is Ebola virus (EBOV) Reston. When EBOV Reston and the highly pathogenic EBOV Zaire were grown in cell culture, comparison of… (More)

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