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VP35 Knockdown Inhibits Ebola Virus Amplification and Protects against Lethal Infection in Mice
TLDR
It is suggested that antisense PMO and P-PMO have the potential to control EBOV infection and are promising therapeutic candidates.
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Two Key Residues in EphrinB3 Are Critical for Its Use as an Alternative Receptor for Nipah Virus
TLDR
EphrinB3 is a bona fide alternate receptor for NiV entry, and two residues in the G–H loop of the ephrin B-class ligands are critical determinants of NiV receptor activity.
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A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire.
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Antiviral Activity of a Small-Molecule Inhibitor of Filovirus Infection
TLDR
In a murine model of ZEBOV infection, delivery of FGI-103 reduces viremia and the viral burden in kidney, liver, and spleen tissues and is associated with subdued and delayed proinflammatory cytokine responses and tissue pathology, which identify a promising antiviral therapeutic candidate for the treatment of filovirus infections.
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Rescue of Recombinant Marburg Virus from cDNA Is Dependent on Nucleocapsid Protein VP30
TLDR
While it was not possible to rescue recombinant MARV when the VP30 plasmid was omitted from transfection, MARV VP30 with a destroyed Zn-binding motif and EBOVVP30 were able to mediate virus recovery.
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Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA
TLDR
The previously developed template for natural filovirus genetic variant naming, (/)///-, is retained, but the type of information added to each field for cDNA clone-derived filoviruses obtained in the laboratory via reverse genetics systems is adapted.
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Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae
TLDR
Adoption of this nomenclature would counter the increasing confusion in genetic variant naming due to the identification of ever more sequences through technological breakthroughs in high-throughput sequencing and environmental sampling and improve figures such as phylograms, alignments, and diagrams.
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Development of a broad-spectrum antiviral with activity against Ebola virus.
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The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals.
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The Ebola Virus Genomic Replication Promoter Is Bipartite and Follows the Rule of Six
TLDR
The results suggest that the EBOV genomic replication promoter is bipartite, consisting of a first element located within the leader region of the genome and a second, downstream element separated by a spacer region.
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