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Laminar Flow Induction of Antioxidant Response Element-mediated Genes in Endothelial Cells
TLDR
The ARE is defined as a novel endothelial shear stress response element and laminar flow activation of antioxidant genes via an ARE-dependent transcriptional mechanism may represent a novel athero-protective and anti-inflammatory mechanism in the vasculature.
Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression.
TLDR
The Nrf2/ARE pathway is identified as an endogenous atheroprotective system for antioxidant protection and suppression of redox-sensitive inflammatory genes, suggesting that targeting the NRF2/are pathway may represent a novel therapeutic approach for the treatment of inflammatory diseases such as atherosclerosis.
MRK, a Mixed Lineage Kinase-related Molecule That Plays a Role in γ-Radiation-induced Cell Cycle Arrest*
TLDR
The data suggest that MRK may mediate γ-radiation signaling leading to cell cycle arrest and thatMRK activity is necessary for the cell cycle checkpoint regulation in cells.
Phenotypic Consequences Resulting from a Methionine-to-Valine Substitution at Position 48 in the HPr Protein of Streptococcus salivarius
TLDR
The results suggested that the capacity of the wild-type cells to preferentially metabolize glucose over non-PTS sugars resulted mainly from inhibition of the catabolism of these secondary energy sources via a HPr-dependent mechanism.
The TAATGARAT Motif in the Herpes Simplex Virus Immediate-Early Gene Promoters Can Confer both Positive and Negative Responses to Cellular Octamer-Binding Proteins When It Is Located within the Viral
TLDR
It is shown that deletion of the upstream IE promoter region containing the TAATGARAT motifs abolishes the inhibitory effect of the cellular octamer-binding proteins Oct-2.4 and Oct- 2.5 on the viral IE promoter.
Diversity of Streptococcus salivarius ptsH Mutants That Can Be Isolated in the Presence of 2-Deoxyglucose and Galactose and Characterization of Two Mutants Synthesizing Reduced Levels of HPr, a
TLDR
A glimpse of the diversity of Streptococcus salivarius ptsH mutants that can be isolated by positive selection on a solid medium containing 2-deoxyglucose and galactose is presented and 13 amino acids that are essential for HPr to properly accomplish its physiological functions are identified.
Morbidity and toxic effects associated with ganciclovir or foscarnet therapy in a randomized cytomegalovirus retinitis trial. Studies of ocular complications of AIDS Research Group, in collaboration
TLDR
The use of foscarnet for the initial treatment of cytomegalovirus retinitis was more frequently limited by the occurrence of toxic reactions, and these toxic reactions rarely had long-term sequelae.
Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow.
TLDR
The data suggest that SphK1 mediates TNF-alpha-induced MCP-1 gene expression through a p38 MAPK-dependent pathway and may participate in oscillatory flow-mediated proinflammatory signaling pathway in the vasculature.
A Functional Interaction between CD46 and DLG4
TLDR
This is the first identification of a direct and cytoplasmic domain-specific interaction between CD46 and an intracellular signaling molecule and provides a molecular mechanism for the polarization of CD46.
Development of a new fusion-enhanced oncolytic immunotherapy platform based on herpes simplex virus type 1
TLDR
HSV-1 was chosen for further development as an oncolytic immunotherapy in this study as it is highly lytic, infects human tumor cells broadly, kills mainly by necrosis and is a potent activator of both innate and adaptive immunity.
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