Suzanne Satterfield

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CONTEXT The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain. OBJECTIVE To compare the effects of discontinuing alendronate treatment after 5 years vs continuing for 10 years. DESIGN AND SETTING Randomized, double-blind trial conducted at 10 US clinical centers that participated in the Fracture Intervention Trial(More)
CONTEXT The Heart and Estrogen/progestin Replacement Study (HERS) was a randomized trial of estrogen plus progestin therapy after menopause. OBJECTIVE To examine the effect of long-term postmenopausal hormone therapy on common noncardiovascular disease outcomes. DESIGN AND SETTING Randomized, blinded, placebo-controlled trial of 4.1 years' duration(More)
OBJECTIVES To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons. DESIGN Prospective cohort study. SETTING Health, Aging and Body Composition Study. PARTICIPANTS Three thousand forty-seven well-functioning older persons (mean age 74.2). MEASUREMENTS Usual(More)
BACKGROUND Whether hearing loss is independently associated with accelerated cognitive decline in older adults is unknown. METHODS We studied 1984 older adults (mean age, 77.4 years) enrolled in the Health ABC Study, a prospective observational study begun in 1997-1998. Our baseline cohort consisted of participants without prevalent cognitive impairment(More)
BACKGROUND Chronic inflammation is associated with processes that contribute to the onset or progression of cancer. This study examined the relationships between circulating levels of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) and total as well as site-specific cancer incidence. (More)
OBJECTIVES To determine how three different physical performance measures (PPMs) combine for added utility in predicting adverse health events in elders. DESIGN Prospective cohort study. SETTING Health, Aging and Body Composition Study. PARTICIPANTS Three thousand twenty-four well-functioning older persons (mean age 73.6). MEASUREMENTS Timed gait,(More)
CONTEXT Aerobic fitness, an important predictor of cardiovascular disease and mortality, is difficult to assess by maximal exercise testing in older adults. Extended walking tests have been examined as outcome predictors in medically ill populations but not in community-dwelling older adults. OBJECTIVE To determine whether an extended walking test(More)
To assess the role of demographic factors and chronic conditions in maintaining mobility in older persons, this study utilized longitudinal data collected as part of the Established Populations for Epidemiologic Studies of the Elderly between 1981 and 1987 on 6,981 men and women aged 65 years and older in East Boston, Massachusetts; Iowa and Washington(More)
OBJECTIVES The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults. BACKGROUND The importance of MetSyn as a risk factor has not previously focused on older adults and deserves further study. METHODS We studied the impact of MetSyn (38% prevalence) on outcomes in 3,035(More)
Previous studies suggest a link between chronic kidney disease (CKD) and cognitive impairment. Whether the longitudinal course of cognitive impairment differs among people with or without CKD is unknown. Data collected in 3034 elderly individuals who participated in the Health, Aging, and Body Composition study were analyzed. Cognitive function was assessed(More)