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Robust cellular reprogramming occurs spontaneously during liver regeneration.
Cellular reprogramming-the ability to interconvert distinct cell types with defined factors-is transforming the field of regenerative medicine. However, this phenomenon has rarely been observed in… Expand
PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.
PR (PRD1-BF1-RIZ1 homologous) domain-containing 16 (PRDM16) drives a brown fat differentiation program, but the mechanisms by which PRDM16 activates brown fat-selective genes have been unclear.… Expand
SnapShot: Brown and Beige Adipose Thermogenesis
Brown and beige adipose tissues have been identified as potential therapeutic targets for combating diet-induced obesity and metabolic disease. Here, we present transcriptional and developmental… Expand
EBF2 promotes the recruitment of beige adipocytes in white adipose tissue
- Rachel R. Stine, Suzanne N. Shapira, +4 authors P. Seale
- Biology, Medicine
- Molecular metabolism
- 14 November 2015
Objective The induction of beige/brite adipose cells in white adipose tissue (WAT) is associated with protection against high fat diet-induced obesity and insulin resistance in animals. The… Expand
EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex.
The transcription factor early B-cell factor 2 (EBF2) is an essential mediator of brown adipocyte commitment and terminal differentiation. However, the mechanisms by which EBF2 regulates chromatin to… Expand
Transcriptional control of brown and beige fat development and function
Adipose tissue, once viewed as an inert organ of energy storage, is now appreciated to be a central node for the dynamic regulation of systemic metabolism. There are three general types of adipose… Expand
Metabolic Regulation of Tissue Stem Cells.
Adult tissue stem cells mediate organ homeostasis and regeneration and thus are continually making decisions about whether to remain quiescent, proliferate, or differentiate into mature cell types.… Expand
Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes
- Anthony R. Angueira, Suzanne N. Shapira, +7 authors P. Seale
- Biology, Medicine
- Cell reports
- 3 March 2020
SUMMARY Brown adipose tissue (BAT) activity protects animals against hypothermia and represents a potential therapeutic target to combat obesity. The transcription factor early B cell factor-2 (EBF2)… Expand
Enhancing brown fat with NFIA
Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor… Expand