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  • Jonathan Gilley, Anjan Seereeram, Kunie Ando, Suzanne Mosely, Michael P. Coleman
  • Biology, Medicine
  • Neurobiology of Aging
  • 2012 (First Published: 1 March 2012)
  • Tauopathies are characterized by hyperphosphorylation of the microtubule-associated protein tau and its accumulation into fibrillar aggregates. Toxic effects of aggregated tau and/or dysfunction ofContinue Reading
  • Gabriel Helmlinger, Ivan Azarov, +5 authors Kirill Peskov
  • Medicine
  • 2019 (First Published: 1 July 2019)
  • Objectives: Studies in murine syngeneic tumors are critical in the development of immune-based therapies, yet there still are knowledge gaps in the functional meaning ( vs . response and resistanceContinue Reading
  • Chiranjeevi Sandi, Antonio Ramos-Montoya, +11 authors Simon Pacey
  • Medicine
  • 2016 (First Published: 15 July 2016)
  • Background: Medical therapy for men with prostate cancer (PCa) is evolving, including recent evidence to support the use of chemotherapy for men with hormone sensitive disease. PI3K/AKT/mTOR pathwayContinue Reading
  • Matthew J. Robinson, Inés C Osma-García, +8 authors Robert W. Wilkinson
  • Medicine
  • 2018 (First Published: 1 July 2018)
  • CD137 is a costimulatory molecule associated with tumour infiltrating lymphocytes and cytotoxic T lymphocytes in particular. Murine anti-CD137 monoclonal antibodies (mAbs) have shown potentContinue Reading