Suzanne Moreland

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This study was designed to investigate the mechanism of endothelin-1 (ET-1) contractions in Staphylococcus alpha-toxin-permeabilized vascular smooth muscle. Rabbit small mesenteric arteries permeabilized with alpha-toxin were mounted for isometric or isotonic force recording or were processed for determination of myosin light chain (MLC) phosphorylation(More)
The binding sites and biochemical effects of angiotensin (A) II were investigated in rat pheochromocytoma (PC12W) cells. Sarcosine1, [125I]-tyrosine4, isoleucine8-AII ([125I]-SI-AII) bound to a saturable population of sites on membranes with an equilibrium dissociation constant (Kd) of 0.4 nM and a binding site maximum of 254 fmol/mg protein. Competitive(More)
The vascular angiotensin (A) II receptor cDNA (AT1a) was transfected into Chinese hamster ovary (CHO) cells to generate the stable cell line CHO-AT1a. This cell line was used to investigate the binding and signal transduction properties of the cloned vascular AT1 receptor. Specific binding of sarcosine1(-)[125I]tyrosine4-isoleucine8-AII ([125I]SI-AII) to(More)
This study was designed to investigate the mechanism of endothelin-1 (ET-1) contractions in Staphylococcus a-toxin-permeabilized vascular smooth muscle. Rabbit small mesenteric arteries permeabilized with ar-toxin were mounted for isometric or isotonic force recording or were processed for determination of myosin light chain (MLC) phosphorylation levels.(More)
Humic acid (MFG) and fat-protected butyric acid (BA) has been shown to modulate energy metabolism and inflammation. Therefore, the objectives of this study were to determine the effects of MFG and BA, alone and in combination, on growth performance and response to lipopolysaccharide (LPS)-induced inflammation in young pigs. An experiment was conducted using(More)
It seems clear that a simple Ca2+ dependent switch (MLC phosphorylation) cannot completely explain all of the disparate mechanical and energetic results obtained under numerous experimental conditions in numerous laboratories. Some of the problems of the simple switch model are that: 1. Force can be developed in the complete absence of increases in MLC(More)
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