Suzanne Joels

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BACKGROUND Deteriorating cognitive function in late life substantially increases the risk for dementia, for other non-cognitive morbidity, for dependency, and early death. AIMS To identify early predictors of late-life cognitive outcome. METHOD Cognitive function, premorbid IQ, and cardiovascular risk exposure were recorded on 1083 subjects on entry to(More)
OBJECTIVE The effect of APOE on dementia may be mediated through dyslipidemia and atherogenesis through its effect on cholesterol metabolism. The authors investigated this possibility among aged survivors from the UK Medical Research Council Trial of the Treatment of Hypertension in Older Adults. DESIGN A total of 370 of 657 survivors from an initial(More)
BACKGROUND Previous longitudinal studies of the association between depression and cognitive dysfunction have had relatively short follow-up periods. This report presents a long-term study of the association between baseline syndromal depression and cognitive outcome measured 9 to 12 years later. METHODS Self-CARE (D) depression, cognitive function and(More)
OBJECTIVE To determine whether a cognitive test package can predict the onset of dementia up to 11 years later, and the extent to which this prediction is independent of that provided by APOE genotype. METHODS Prospective cohort study based on 54 general practices in the UK; 657 survivors of the 1088 participants in the MRC treatment trial of hypertension(More)
OBJECTIVE The authors asked whether polymorphic variation at three genes related to vascular disease, and other vascular disease risk factors, determine late-life depression. METHODS A group of 370 participants, representing 57% of survivors of an initial cohort of 1,083 participants in the Medical Research Council treatment trial of hypertension in older(More)
Background Deteriorating cognitive Deteriorating cognitive function in late life substantially increases function in late life substantially increases the risk for dementia, for other non-the risk for dementia, for other non-cognitive morbidity, for dependency, and cognitive morbidity, for dependency, and early death. early death. Aims Aims To identify(More)
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