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- C. W. Kwon, Bryan W Luikart, +6 authors Luis F. Parada
- Neuron
- 2006
CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number, thus providing compelling etiology for macrocephaly and Lhermitte-Duclos disease. PTEN mutations in… (More)
- Gang Wu, Alberto Broniscer, +18 authors Suzanne J. Baker
- Nature Genetics
- 2012
To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of… (More)
- Barbara S. Paugh, Chunxu Qu, +14 authors Suzanne J. Baker
- Journal of clinical oncology : official journal…
- 2010
PURPOSE
To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG).
PATIENTS AND METHODS
We conducted a high-resolution analysis of genomic… (More)
- Nader Chalhoub, Suzanne J. Baker
- Annual review of pathology
- 2009
PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-kinase pathway, which regulates growth, survival, and proliferation. These key signaling components are two of… (More)
- G. W. Robinson, Matthew Parker, +47 authors Richard J. Gilbertson
- Nature
- 2012
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes of 37 tumours and… (More)
- C. W. Kwon, Xiaoyan Zhu, +6 authors Suzanne J. Baker
- Nature Genetics
- 2001
Somatic inactivation of PTEN occurs in different human tumors including glioblastoma, endometrial carcinoma and prostate carcinoma. Germline mutations in PTEN result in a range of phenotypic… (More)
- Alfonso Lavado, Oleg V. Lagutin, Lionel M. L. Chow, Suzanne J. Baker, Guillermo Oliver
- PLoS biology
- 2010
The dentate gyrus has an important role in learning and memory, and adult neurogenesis in the subgranular zone of the dentate gyrus may play a role in the acquisition of new memories. The homeobox… (More)
- Gang Wu, Alexander K. Diaz, +44 authors Suzanne J. Baker
- Nature Genetics
- 2014
Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas… (More)
- Susan Landau, Rayhan A. Lal, James P. O'Neil, Suzanne J. Baker, William J. Jagust
- Cerebral cortex
- 2009
Recent studies have emphasized the importance of dopamine projections to the prefrontal cortex (PFC) for working memory (WM) function, although this system has rarely been studied in humans in vivo.… (More)
- Samantha A. Cicero, Dianna A. Johnson, +6 authors Michael A. Dyer
- Proceedings of the National Academy of Sciences…
- 2009
It was previously reported that the ciliary epithelium (CE) of the mammalian eye contains a rare population of cells that could produce clonogenic self-renewing pigmented spheres in culture. Based on… (More)