Suzanne F. Roland

Learn More
New metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a potent mutagen and carcinogen formed during cooking of meat or fish, have been identified and quantitated in the urine and bile of rats. Administration was either by a pulse gavage dose of 40 mg/kg [2-14C]IQ or by dietary intake of 300 ppm IQ for 6 weeks. The metabolites were isolated by(More)
OBJECTIVE The purpose of this study is to describe the neuroimaging (CT and MR imaging) findings in liver transplant patients who develop severe neurologic side effects during immunosuppressive therapy with tacrolimus and to correlate these findings with clinical signs and tacrolimus levels in blood. SUBJECTS AND METHODS Brain CT and/or MR imaging was(More)
New metabolites of 2-amino-3-methylimidazo|4,5-/]quinoline (IQ), a potent mutagen and carcinogen formed during cooking of meat or fish, have been identified and quantitated in the urine and bile of rats. Admin istration was either by a pulse gavage dose of 40 mg/kg |2-MC]IQ or by dietary intake of 300 ppm IQ for 6 weeks. The metabolites were isolated by(More)
  • 1