Suzanne Cunningham

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In the present experiments, we examined the roles of opiate receptor subtypes in the nucleus accumbens in spontaneous motor behavior and responding for conditioned reward. Locomotor activity was measured using photocell cages and reward-related responding was determined in the conditioned reinforcement (CR) paradigm. In the CR paradigm, food-deprived rats(More)
The following experiments were performed to ascertain the role of the nucleus accumbens in opiate-dopamine interactions using measures of locomotor activity. Three separate experiments were carried out. In Experiment 1, rats received systemic morphine (10 mg/kg IP) or saline (1 ml/kg IP) every other day for 5 days, followed by systemic amphetamine (1.5(More)
Although manipulation of second messenger systems is widespread in cell biology, there are few experiments examining the consequences of such manipulation on behavior. In three separate experiments, we extended earlier work by Miller and Kelly (1975) that examined the behavioral effects of microinfusion of cholera toxin (CTX) into the nucleus accumbens (N.(More)
The present study determined if environmental enrichment modifies the effects of prenatal cocaine on open field activity, social interaction and dopamine transporter (DAT) function in the medial prefrontal cortex (mPFC) in rats. Cocaine (40 mg/kg) or saline was administered (s.c.) to pregnant dams from gestation days 8 to 20 (PCOC and PSAL, respectively).(More)
We investigated opiate-amphetamine interactions within the nucleus accumbens in responding for conditioned reward. Separate groups of animals received 4-day intra-accumbens treatment with either saline, morphine (0.5 microgram/0.5 microliter), [D-Ala2 NMe-Phe4 Gly-ol5]-Enkephalin (DAMGO; 1.0 micrograms/0.5 microliter), or [D-Pen2,5]-Enkephalin (DPEN; 2.0(More)
Bilateral transection of the pelvic and/or hypogastric nerves, which convey afferent activity from the reproductive tract, was performed to ascertain the role of these nerves in the analgesic and motoric effects of vaginocervical mechanostimulation (VS) in rats. Two indices of analgesia were used: tail flick latency to radiant heat (TFL) and vocalization(More)
Previous research has demonstrated increased pain threshold during copulation, gestation, and parturition in animals. In the laboratory, mechanostimulation of the vaginocervical region in many animals, as well as humans, can increase responsiveness to noxious but not to innocuous stimuli. This increased pain inhibition to vaginocervical stimulation, which(More)
Reflexive ovulation in the rat, induced by caesarean section performed on day 22 of pregnancy, was blocked by prior bilateral transection of the pelvic and/or hypogastric nerves, which convey afferent activity from the reproductive tract. Tubal ova and hemorrhagic ovarian follicles were counted 24 h after bilateral nerve transections or sham neurectomy.(More)
OBJECTIVE to evaluate the Midwifery Ventouse Practitioners' (MVPs) Course and the MVPs' perception of its effect on their practice. DESIGN qualitative and quantitative. PARTICIPANTS 18 midwives who had completed the MVP course at Bournemouth University 1998-2000. DATA COLLECTION focus group (n=8) and postal questionnaire (n=18). FINDINGS important(More)
ii In memory of Larry Leafgren Philippians 4:13 iii ACKNOWLEDGEMENTS I would like to thank Drs. Gebisa Ejeta and Sylvie Brouder for their guidance on this project and for sharing their wealth of expertise. To the remaining members of my committee, Drs. Cliff Weil, Mike Mickelbart, and Rebecca Doerge, thank you for your feedback and support in pursuing this(More)