Suzanne Carty

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The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other(More)
Diagnostic medical ultrasound (US) uses high-frequency sound waves (2–15 MHz), in real-time visualization of both superficial and deep structures. From its early application in obstetrics, it has now developed into the most commonly used imaging technique accounting for .40% of all radiological examinations. Technological advances in piezoelectric(More)
BACKGROUND Alzheimer's disease manifests considerable heterogeneity, the cause of which is unknown. AIMS To determine the familial (genotypic) influence on phenomenology (phenotype) in Alzheimer's disease. METHOD Affected sibling pairs with Alzheimer's disease were assessed for a range of cognitive and non-cognitive symptoms. Resemblance for phenotypic(More)
Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late(More)
OBJECTIVE This study sought to determine the efficacy of post-operative wound infiltration with local anaesthetic following paediatric appendicectomy. METHOD In a randomised, controlled, prospective, clinical trial children aged between five and sixteen years were assigned to one of three treatment arms; infiltration of the surgical wound with(More)
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