Suzanne B. Hartley

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Interactions between B and T cells are essential for most antibody responses, but the dynamics of these interactions are poorly understood. By two-photon microscopy of intact lymph nodes, we show that upon exposure to antigen, B cells migrate with directional preference toward the B-zone-T-zone boundary in a CCR7-dependent manner, through a region that(More)
Type 1 diabetes and other organ-specific autoimmune diseases often cluster together in human families and in congenic strains of NOD (nonobese diabetic) mice, but the inherited immunoregulatory defects responsible for these diseases are unknown. Here we track the fate of high avidity CD4 T cells recognizing a self-antigen expressed in pancreatic islet beta(More)
Recent attempts to examine the role of different mechanisms in generating a positive abundance-occupancy relationship failed to properly distinguish between Brown's (1984) sampling artefact, and the form of relationship to be expected from a random distribution of individuals. Because random distributions generate a positive relationship, one can never(More)
The temporal distribution of monthly heating degree days (HDD) approximates a bell-shaped curve, usually with a January maximum. The first moment, or centroid, of this distribution can be taken as the midpoint of the heating season. Analysis of seasonal HDD centroids reveals significant inter-decadal trends in the Northern Plains. From 1950 to 1990, the(More)
Implementing clinical trials involving participants with diminished capacity, such as elderly residents in care homes, stroke survivors, those with a learning disability, can be challenging in terms of balancing complex service and patient needs with methodological rigor. The key challenges identified here are the appropriate tailoring of recruitment(More)
BACKGROUND There are recognised gaps between evidence and practice in general practice, a setting which provides particular challenges for implementation. We earlier screened clinical guideline recommendations to derive a set of 'high impact' indicators based upon criteria including potential for significant patient benefit, scope for improved practice and(More)
BACKGROUND Delirium is the most frequent complication among older people following hospitalisation. Delirium may be prevented in about one-third of patients using a multicomponent intervention. However, in the United Kingdom, the National Health Service has no routine delirium prevention care systems. We have developed the Prevention of Delirium Programme,(More)
Action to Support Practices Implementing Research Evidence (ASPIRE) is an NIHR-funded programme aiming to develop and evaluate interventions to promote the uptake of NICE recommendations in general practice. Multifaceted intervention packages targeting key recommendations will be evaluated using anonymised, routinely collected electronic health records in(More)
The use of routine datasets in the evaluation of interventions in clinical trials is increasing. Action to Support Practices Implementing Research Evidence (ASPIRE) is an NIHR Programme aiming to develop and test ways to support general practices in implementing key NICE recommendations. Multifaceted intervention packages have been developed to target four(More)
BACKGROUND Rheumatoid Arthritis (RA) is one of the most common autoimmune diseases, affecting approximately 1% of the UK adult population. Patients suffer considerable pain, stiffness and swelling and can sustain various degrees of joint destruction, deformity, and significant functional decline. In addition, the economic burden due to hospitalisation and(More)