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Overexpression of YAP and TAZ Is an Independent Predictor of Prognosis in Colorectal Cancer and Related to the Proliferation and Metastasis of Colon Cancer Cells
Background and Objective Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are nuclear effectors of the Hippo pathway. Although they are abundantly expressed… Expand
TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin
The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. We previously showed that the pivotal effector of this… Expand
fied, along with their associated protein‐protein interaction networks and Kyoto Encyclopedia of Genes and Genomes
The aim of the present study was to evaluate the potential network of arsenic trioxide (ATO) target genes in pancreatic cancer. The DrugBank, STITCH, cBioPortal, Kaplan-Meier plotter and Oncomine… Expand
Role of Twist in vasculogenic mimicry formation in hypoxic hepatocellular carcinoma cells in vitro.
Vasculogenic mimicry (VM) refers to the unique ability of highly aggressive human tumor cells to form matrix-rich networks de novo when cultured on a three-dimensional matrix, thus mimicking… Expand
p53-dependent CD51 expression contributes to characteristics of cancer stem cells in prostate cancer
Castration-resistant prostate cancer (CRPC), which is considered to contain cancer stem cells (CSCs), leads to a high relapse rate in patients with prostate cancer (PCa). However, the markers of… Expand
The prognostic value of the platelet-to-lymphocyte ratio in acute coronary syndrome: a systematic review and meta-analysis.
BACKGROUND AND AIM The aim of this study was to investigate whether the platelet-to-lymphocyte ratio (PLR) is an independent predictor of all-cause mortality and cardiovascular (CV) events in… Expand
A20 enhances the radiosensitivity of hepatocellular carcinoma cells to 60Co-γ ionizing radiation
The radioresistance of hepatocellular carcinoma (HCC) cells is a critical obstacle for effectively applying radiotherapy (RT) in HCC treatment. NF-κB, an important transcription factor, can influence… Expand
Polymorphisms of aquaporin5 gene in chronic obstructive pulmonary disease in a Chinese population.
- Y. Ning, B. Ying, Suxia Han, Baiding Wang, X. Wang, Fuqiang Wen
- Swiss medical weekly
- 4 October 2008
BACKGROUND Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality. It is influenced by both environmental and genetic factors. Aquaporin5 plays a critical… Expand
Characterization of a novel p110&bgr;‐specific inhibitor BL140 that overcomes MDV3100‐resistance in castration‐resistant prostate cancer cells
BACKGROUND Our previous studies demonstrated that the class IA PI3K/p110β is critical in castration-resistant progression of prostate cancer (CRPC) and that targeting prostate cancer with… Expand
The mechanism of calcitriol in cancer prevention and treatment.
Calcitriol (1, 25-dihydroxyvitamin D3) is the most biologically active metabolite derived from the secosteroid hormone vitamin D. Apart from its calcium homeostatic effects, epidemiological studies… Expand