Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells
- Melissa T Adams, J. M. Dwulet, B. Blum
- BiologyeLife
- 7 July 2021
It is shown here that Robo βKO islets have reduced synchronized intra-islet Ca2+ oscillations among β cells in vivo, suggesting that the islet architecture itself is required for synchronized Ca2+, and has implications for understanding structure-function relationships in the islets during progression to diabetes as well as engineering islets from stem cells.
The Anna Karenina Model of β-Cell Maturation in Development and Their Dedifferentiation in Type 1 and Type 2 Diabetes
- Sutichot D. Nimkulrat, M. Bernstein, Zijian Ni, Jared Brown, C. Kendziorski, B. Blum
- Biology, MedicineDiabetes
- 17 February 2021
An unbiased approach is shown that despite some similarities between immature and dedifferentiated β-cells, β-cell dedifferentiation in the two mouse models is not a reversal of developmental ontogeny and is different between different types of diabetes.
Genomic and Metagenomic Analysis of Diversity-Generating Retroelements Associated with Treponema denticola
- Sutichot D. Nimkulrat, Heewook Lee, T. Doak, Yuzhen Ye
- BiologyFrontiers in Microbiology
- 3 June 2016
This is the first comprehensive study to characterize the DGRs associated with T. denticola in individual genomes as well as human microbiomes, demonstrating the importance of utilizing both individual genomes and metagenomes for characterizing the elements, and for analyzing their diversity and distribution in human populations.
Islet Architecture Controls Synchronous β Cell Response to Glucose in the Intact Mouse Pancreas in vivo
- Melissa T Adams, C. A. Reissaus, B. Blum
- Biology, Computer ScienceSSRN Electronic Journal
- 12 December 2019
It is shown here that Robo { beta}KO islets lose synchronized intra-islet Ca2+ oscillations between {beta} cells in vivo, suggesting that the islet architecture itself is required for synchronized Ca2- oscillations.
Synchronized β cell response to glucose is lost concomitant with loss of islet architecture in Robo deficient islets of Langerhans in vivo
- Melissa T Adams, C. A. Reissaus, B. Blum
- BiologybioRxiv
- 12 December 2019
It is shown here that Robo βKO islets lose synchronized intra-islet Ca2+ oscillations between β cells in vivo, suggesting that the islet architecture itself is required for synchronized Ca2+, and has implications for understanding structure-function relationships in the islets during progression to diabetes as well as engineering islets from stem cells.