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Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
Biased agonists of the kappa opioid receptor may relieve intractable itch without causing unwanted side effects. Itch relief from biased agonists Activating the kappa opioid receptor (KOR) canExpand
Opioid Self-administration in the Nerve-injured Rat: Relevance of Antiallodynic Effects to Drug Consumption and Effects of Intrathecal Analgesics
TLDR
Opioid self-administration is significantly altered by nerve injury, with rate of drug intake being correlated with reversal of allodynia, and the neurobiologic mechanisms that regulate opioid consumption in rats seem to be altered after nerve injury. Expand
Dose–Effect Functions for Cocaine Self-Administration: Effects of Schedule and Dosing Procedure
TLDR
Responding was maintained in rats under either variable-interval or fixed-ratio schedules of cocaine infusion, indicating that procedural variables can alter dose-response curves for cocaine self-administration. Expand
Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task
TLDR
The titration 5CSRTT method is an efficient training procedure for assessing attention and can be utilized to assess the limit in performance ability across subjects and various schedule manipulations. Expand
In Vivo Characterization of a Novel Phenylisothiocyanate Tropane Analog at Monoamine Transporters in Rat Brain
TLDR
The irreversible effects of HD-205 in vivo in rats after intracranial injection was evaluated to evaluate the neuroanatomical basis of DAT-mediated cocaine effects and a strategy of site-specific chemical blockade of transporters was proposed. Expand
Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation
TLDR
It is demonstrated that drug self‐administration can be applied to questions other than drug abuse, and provides an additional measure for development of novel therapeutic strategies for chronic pain treatment. Expand
Involvement of the Lateral Amygdala in the Antiallodynic and Reinforcing Effects of Heroin in Rats after Peripheral Nerve Injury
TLDR
The lack of effect of &bgr;-funaltrexamine on heroin self-administration in sham-operated subjects suggests that opioids maintain self-Administration through a distinct mechanism in the presence of pain. Expand
Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: evidence from focal injections of β-funaltrexamine
TLDR
The caudal portion of the NAcc and its output sites merit further investigation regarding the reinforcing effects of heroin. Expand
Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat
TLDR
It is found that chronic social stress alters the neurobiological response to surgical injury, resulting in slowed recovery, and maybe useful for future interventional studies examining the mechanistic interactions between depression and risk of CPSP. Expand
Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task.
TLDR
It is demonstrated that abdominal inflammation induced by lactic acid produces robust disruption in a visual attention-based operant task and that this disruption is reversed by analgesics. Expand
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